| 复方乳酸左氧氟沙星阴道栓的急性毒性研究 |
| |
| 引用本文： | 纪忠岐,闫志玲,包翠屏,董福祥. 复方乳酸左氧氟沙星阴道栓的急性毒性研究[J]. 河南大学学报(医学版), 2005, 24(2): 37-37,41 |
| |
| 作者姓名： | 纪忠岐 闫志玲 包翠屏 董福祥 |
| |
| 作者单位： | 河南大学药学院,药理教研室,河南,开封,475001;开封市卫校附属医院,药剂科,河南,开封,475000;河南省人民医院,药械科,河南,郑州,450003 |
| |
| 摘 要： | 目的观察复方乳酸左氧氟沙星阴道栓对家兔1次性给药后对家兔阴道的急性反应及动物死亡情况。方法将家兔仰卧固定,于阴道内1次置入药物0.2g/kg.使药物与阴道黏膜接触6h,观察动物给药后即刻及14d内动物的全身反应情况。结果给药后,动物无死亡和全身毒性反应。结论复方乳酸左氧氟沙星阴道栓对家兔的急性毒性实验无发现明显毒性反应。
|
| 关 键 词： | 复方乳酸左氧氟沙星 阴道栓 阴道黏膜 急性毒性 |
| 文章编号： | 1672-7606(2005)02-0037-01 |
Study on acute viginal toxicity of Compound Levofloxacin Lactate Vaginal Suppository |
| |
| JI Zhong-qi,YAN Zhi-ling,BAO Cui-ping,DONG Fu-xiang. Study on acute viginal toxicity of Compound Levofloxacin Lactate Vaginal Suppository[J]. Journal of Henan University, 2005, 24(2): 37-37,41 |
| |
| Authors: | JI Zhong-qi YAN Zhi-ling BAO Cui-ping DONG Fu-xiang |
| |
| Affiliation: | JI Zhong-qi1,YAN Zhi-ling2,BAO Cui-ping1,DONG Fu-xiang3 |
| |
| Abstract: | Objective: To observe the acute reacts and death number of animals when Compound Levofloxacin Lactate Vaginal Suppository was given to rabbit for only one time. Methods: Rabbit was fastened supine, medicine was put into vagina with a dose of 0.2 g/kg one time, medicine was kept in touch with vaginal mucous membrane for six hours, and the systemic reacts were observed at once and in fourteen days. Results: No animal died and had systemic toxicity reacts after the medicine was given. Conclusion: No evident toxicity reacts were found during the acute and toxicity experiment for rabbit given by Compound Levofloxacin Lactate Vaginal Suppository. |
| |
| Keywords: | compound levofloxacin lactate vaginal suppository vaginal mucous membrane acute and toxicity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
