Opioid-receptor blockade reduces nose-poke self-stimulation derived from medial entorhinal cortex |
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Authors: | K G Reymann S Wulcko T Ott H Matthies |
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Affiliation: | 1. RISC, Johannes Kepler Universität, Linz, Austria;2. Deutsches Elektronen-Synchrotron DESY, Zeuthen, Germany;3. PRISMA Cluster of Excellence, Institut für Physik, Johannes Gutenberg-Universität, Mainz, Germany;4. Institut des Hautes Études Scientifiques, IHES, Bures-sur-Yvette, France |
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Abstract: | Rats were trained to nose-poke for intracranial self-stimulation (SS) with electrodes unilaterally implanted in the medial entorhinal cortex. The acute effects of naloxone (NX; 0.1-10 mg/kg, IP) on a continuous reinforcement schedule were determined. Reductions in the self-stimulation rates occurred only at moderate doses (median of individual changes = -36% at 1 and 5 mg/kg), whereas the high dose (10 mg/kg) was ineffective. None of the doses influenced operant behavior. These results are consistent with the hypothesis that endogenous opioid-opiate receptor mechanisms play a modulatory role in SS reward. Considering that NX was administered systemically the action of the drug on reinforcement levels may be mediated by a site distinct from the locus of stimulation. |
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