| 伊马替尼治疗慢性粒细胞白血病加速期致尿崩症1例及文献复习 |
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| 引用本文： | 何国民,钟宜干,徐娟,蔡亚云.伊马替尼治疗慢性粒细胞白血病加速期致尿崩症1例及文献复习[J].苏州大学学报(自然科学版),2008,28(6):1010-1011,1021. |
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| 作者姓名： | 何国民 钟宜干 徐娟 蔡亚云 |
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| 作者单位： | 如皋市人民医院,血液科,江苏如皋,226500 |
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| 摘 要： | 目的 通过观察伊马替尼治疗慢性粒细胞白血病过程中出现罕见毒副反应,探讨甲磺酸伊马替尼在治疗慢性粒细胞白血病中的安全性.方法 对1例伊马替尼治疗晚期慢性粒细胞白血病加速期的过程中出现罕见毒副反应的临床资料进行分析,并结合文献复习.结果 1例确诊为慢性粒细胞白血病的患者接受甲磺酸伊马替尼治疗后,出现尿崩症、窦性心动过速伴肌肉损坏,停药70多天再次减量服用后又出现类似症状.结论 伊马替尼治疗慢性粒细胞白血病加速期可能出现罕见的严重不良反应.
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| 关 键 词： | 慢性粒细胞 白血病 伊马替尼 尿崩症 肌肉损坏 窦性心动过速 |
A Case of Diabetes Insipidus Caused by Imatinib in the Treatment of Patients with Chronic Granulocytic Leukemia in Accelerated Phase and Review of the Literature |
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| HE Guo-ming,ZHONG Yi-gan,XU Juan,CAI Ya-yun.A Case of Diabetes Insipidus Caused by Imatinib in the Treatment of Patients with Chronic Granulocytic Leukemia in Accelerated Phase and Review of the Literature[J].Suzhou University Journal of Medical Science,2008,28(6):1010-1011,1021. |
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| Authors: | HE Guo-ming ZHONG Yi-gan XU Juan CAI Ya-yun |
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| Abstract: | Objective To explore the safety of imatinib mesylate,observe its rare side effects as it is applied to chronic myeloid leukemia(CML).Methods The clinicl data obtained from one patient,who was treated with imatinib mesylate after diagnosed as CML in accelerated phase was analysed and combinding with previous related literatures.Results Diabetes insipidus,sinus tachycardia and muscle injury occured to a case confirmed as CML in accelerated phase after imatinib mesylate was adminis-tered.The same side effects ... |
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| Keywords: | chronic leukemia imatinib diabetes insipidus muscle damage sius tachycardia |
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