左旋多巴促进骨折愈合的实验研究与临床应用

选用本地山羊３０只，随机分为实验组与对照组，每组各１５只。每只羊均于同侧股骨中段及胚骨中段造成横形骨折，股骨行梅花针内固定，胫骨行斯氏针内固定。实验组口服左旋多巴片。术后２、４、６、８、１２周分别行Ｘ线检查，肉眼观察，组织学检查，扫描电镜检查和血液化学检查。结果表明实验组骨痂形成早，生长快，骨折愈合明显优于对照组。在实验研究的基础上，１９８９年１０月～１９９２年１２月，采用左旋多巴治疗骨折２１０例，疗效满意。

AESTRACTSEXPERIMENTAL STUDY OF L-DOPU IN THE ENHANCEMENT OF FRACTURE HEALINGAND ITS CLINICAL APPLIATION

hirty native goats were equally divided into two groups at random.A transverse fracture wasmade at the middle of the femur and tibia on the same side .The c;pver-shaped pin was used to fix thefemur and the Kirshners wire for the tibia.The experimental animals were given L-Dopu tablers.The animals were undergone the gross examination,roentgenographic eXamination, histolgical study,electron microseopic scanning and the examination of blood chemistry at 2,4,6,8and 12 weeks afteroperation,respectively.The result indicated that in the expermental group,the callus formation andthe fracture healing were all far supporior to that of the control;Basing on the experimental results,from October 1989 throrgh December 1992,L-Dopu was used to treat 210 fractures with satisfactoryresults.