α1受体阻滞剂与射精障碍

α1受体阻滞剂因其良好的疗效、安全和耐受性已成为治疗BPH等男性泌尿生殖系统疾病常用一线药物之一,然而随着α1受体阻滞剂的广泛应用,其对男性生殖系统的不良反应也逐渐凸显,尤其是导致了不同程度的射精障碍。本文简要介绍了α1受体在男性生殖系统的分布和功能及其与射精的关系,着重阐述了α1受体阻滞剂导致的射精障碍现象及其产生机制,为进一步探讨该类药物对男性性功能和生殖能力影响以及临床用药提供参考。

al-adrenoceptor Antagonists and Ejaculation Dysfunction

alpha1-adrenoceptor antagonists are first-line agents for the treatment of lower urinary tract symptoms suggestive of benign prostatic hyperplasia, while their adverse effects on sexual function are reported frequently in recent years, especially the induction of ejaculatory dysfunction. This review presents the distribution of alphal-adrenoceptors in the male genital system and the relationship of alpha1-adrenoceptors with ejaculatory function. It also highlights the interesting phenomenon of ejaculatory dysfunction related to these drugs and its possible mechanism, with the intention to provide some essential clues for further research on this problem as well as some references to safer use of these drugs in clinical settings.