中国小型猪心导管介入冠状动脉栓塞心肌梗塞模型的建立

目的 建立中国小型猪心导管介入冠状动脉栓塞心肌梗塞模型，为基础医药学研究尤其为干细胞移植治疗冠心病研究提供新的方法。方法与结果 选用心脏及冠状动脉系统的解剖生理特点与人相似的中国小型猪，应用心导管介入技术将栓子定位植入冠状动脉，阻断冠状动脉血流，造成心肌梗塞，形成与临床相似的病理生理过程，从而建立了普遍适用于急性与慢性实验研究的中国小型猪心肌梗塞模型。结论 该模型稳定，方法先进，可进行准确的定位、定量、动态观测，结果可靠，重复性好，可广泛用于药理学、病理生理学以及细胞工程学等各个领域的研究。

Establishment of Chinese Miniswine Model of Myocardial Infarct by Catheterization in Coronary Artery

Objective To provide a new method for the research of fundamental medicines and especially for the stem cell transplantation by setting a Chinese miniswine model of myocardial infa rct.Methods and Results By cardiac catheteriza-tion,an embolus was transplanted in to the coronary arteries of Chinese miniswines which are similar to those of human be-ings.The embolus blocked the coronary blood blow and caused myocardial i nfarct.Thus,a pathologic and physiological course similar to clinical conditio n was developed.This myocardial inf arct model can be used in both acute an d chronic experiments.Conclusion The new animal model is advanced and s table;it has the advantage of exact l ocalization,quantitative measurement and dynam ic observation.So,it can be widely a pplied in the research fields of pharmacology,pathophysiology,cell engineering,etc.