| 甲磺酸酚妥拉明抗心律失常的初步研究 |
| |
| 引用本文： | 许菲.甲磺酸酚妥拉明抗心律失常的初步研究[J].亚太传统医药,2012,8(4):35-36. |
| |
| 作者姓名： | 许菲 |
| |
| 作者单位： | 蚌埠市第三人民医院,安徽蚌埠,233000 |
| |
| 摘 要： | 目的:通过观察甲磺酸酚妥拉明(PM)对正常大鼠心室肌细胞钠电流(INa)的影响,以探讨其抗心律失常的作用机制。方法:采用膜片钳全细胞记录技术记录了PM对单个大鼠心室肌细胞钠电流的影响。结果:动物实验表明PM降低正常心室肌细胞INa电流密度峰值,钠离子通道失活加速,失活后再恢复时间延迟。结论:PM对心室肌细胞0相动作电位快钠电流有抑制作用,能使快速性室性心律失常的发生率降低。
|
| 关 键 词： | 甲磺酸酚妥拉明 钠离子通道电流 膜片钳技术 心律失常 |
The Primary Research of the Mechanism of anti-arrhythmia by phentolamine mesylate |
| |
| Xu Fei.The Primary Research of the Mechanism of anti-arrhythmia by phentolamine mesylate[J].Asia-Pacific Traditional Medicine,2012,8(4):35-36. |
| |
| Authors: | Xu Fei |
| |
| Institution: | Xu Fei(The pharmacy department of Bengbu Third People’s Hospital of Anhui Province,Anhui 233000,China) |
| |
| Abstract: | Objective:Through observation the effect of phentolamine mesylate(PM) on sodium current(INa) in rat ventricular myocytes,in order to explore its antiarrhythmic effect mechanism.Methods:the whole cell patch clamp technique was used to record the effect of PM on the sodium currents in single rat ventricular myocytes.Results:animal experiments show that PM reduces INa current density peak in normal ventricular muscle cells,the inactivation of sodium channel was accelerated,recovery time was delayed after inactivation.Conclusion:PM could inhibit the 0 phase of action potential fast sodium current inhibition in ventricular myocytes,and decrease the incidence of ventricular arrhythmia. |
| |
| Keywords: | Phentolamine Mesylate Sodium Ion Channel Currents Patch-clamp Technique Arrhythmia |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
