骨组织工程中的应力与生长

力学环境是骨组织所处的重要微环境之一 ,应力 (应变 )可促进细胞增殖 ,引起细胞骨架重排及细胞形态的变化 ,加速细胞基质矿化 ,刺激细胞因子及骨代谢激素的分泌 ,从而调节骨代谢、促进骨组织的生长与重建。但体外培养时 ,应力(应变 )水平和细胞反应程度间的关系及细胞间信号转导等的机制还不是十分清楚 ,而这些都是体外培养组织所必须解决的问题 ,因此 ,本文综述了应力对骨组织及成骨细胞、软骨细胞的影响与机理 ,对今后研究应力对骨组织工程化培养的影响具有十分重的意义

The relationship between stress and growth in bone tissue engineering

The mechanical fields is the important micro enviroment which bone tissue locate in.The envioment of the stress(strain) can prompted the proliferative response of cells,induce the rearrangement of cytoskeleton and the change of cellular shape,accelerate the mineralization of cell matrix,boost the release of cytokine and bone honmone,then control the metabolism of bone,stimulates bone formation and bone remodeling,however,the correlation betweenstress(strain)magnitude and the extent of cellular response,the mechanism of cellular signal transduction are not definitively determined,these questions,however,must be resolved during tissue culture in vitro.based on these problems,this article summarize the effect of stress(strain) on osteoblast and chondrocyte and its mechanism,the research about the reations of bone engineering culture to stress(strain) will play a important role in bone tissue engineering.