| 中药复方气雾剂喘立停中麻黄碱和伪麻黄碱含量及微粒分数的测定 |
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| 引用本文： | 余琪,闻聪,周丹英. 中药复方气雾剂喘立停中麻黄碱和伪麻黄碱含量及微粒分数的测定[J]. 中国医药工业杂志, 2008, 39(9) |
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| 作者姓名： | 余琪 闻聪 周丹英 |
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| 作者单位： | 1. 浙江省中药研究所,浙江杭州,310023
2. 上海医药工业研究院,上海,200437 |
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| 摘 要： | 用HPLC法测定中药复方气雾剂喘立停中麻黄碱和伪麻黄碱的含量,双冲程取样器法测定气雾剂中有效成分的微粒分数(FPF)。盐酸麻黄碱和盐酸伪麻黄碱的平均回收率为100.4%和99.60%,RSD为1.47%和0.72%。随处方中乙醇含量的增加或贮存温度的降低,制品FPF减小。
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| 关 键 词： | 喘立停气雾剂 定量吸入剂 盐酸麻黄碱 盐酸伪麻黄碱 高效液相色谱 微粒分数 |
Determination of Ephedrine, Pseudoephedrine and Fine Particle Fraction in Chuanliting Metered Dose Inhalers |
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| YU Qi,WEN Cong,ZHOU Dan-ying. Determination of Ephedrine, Pseudoephedrine and Fine Particle Fraction in Chuanliting Metered Dose Inhalers[J]. , 2008, 39(9) |
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| Authors: | YU Qi WEN Cong ZHOU Dan-ying |
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| Abstract: | A HPLC method was adopted for the determination of ephedrine and pseudoephedrine in the traditional Chinese medicine aerosol Chuanliting.Two-stage impinger was used to determine the fine particle fraction(FPF)of active ingredient in the metered dose inhaler(MDI).The results showed that the average recoveries of ephedrine hydrochloride and pseudoephedrine hydrochloride were 100.4% and 99.60% with RSDs of 1.47% and 0.72%,respectively.The percentage of FPF was decreased with the increase of ethanol content or the lowering of the stored temperature. |
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| Keywords: | Chuanliting aerosol metered dose inhaler ephedrine hydrochloride pseudoephedrine hydrochloride HPLC fine particle fraction |
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