早发型子痫前期患者血浆胎盘生长因子水平与围生结局关系分析

目的 探讨早发型子痫前期(EOPE)患者血浆胎盘生长因子(PLGF)水平与围生结局关系。方法 138例EOPE患者,于分娩当日采集其空腹静脉血检测PLGF水平,将PLGF水平≤12 pg/ml的67例患者作为低PLGF组, PLGF水平>12 pg/ml的71例患者作为高PLGF组。记录并比较两组患者围生结局(分娩孕周、羊水过少、羊水染粪、小于胎龄儿)及新生儿情况[新生儿体重、1 min Apgar评分、乳酸(LAC)、血糖、血钙、新生儿重症监护病房(NICU)住院时间]。结果 高PLGF组分娩孕周(35.43±1.39)周大于低PLGF组的(33.27±2.02)周,差异有统计学意义(P<0.05);高PLGF组羊水过少、羊水粪染、小于胎龄儿的占比分别为19.72%、30.99%、15.49%,均低于低PLGF组的41.79%、52.24%、49.25%,差异均有统计学意义(P<0.05)。高PLGF组的新生儿体重(2635.25±412.07)g明显高于低PLGF组的(1809.23±415.13)g,新生儿1 min Apgar评分(8.46±1.02)分、乳酸(3.47±1.59)mmol/L、血钙(1.18±0.21)mmol/L、血糖(3.61±1.39)mmol/L均明显优于低PLGF组的(8.01±1.28)分、(6.03±2.79)mmol/L、(1.03±0.20)mmol/L、(3.17±1.20)mmol/L, NICU住院时间(10.12±9.47)d明显短于低PLGF组的(16.73±9.85)d,差异均具有统计学意义(P<0.05)。结论 EOPE患者血浆PLGF水平对于评价围生结局和新生儿状况有一定价值,高水平PLGF患者围生结局和新生儿情况优于低水平PLGF。

Analysis of plasma placental growth factor levels and perinatal outcomes in patients with early-onset pre-eclampsia

Objective To discuss the correlation between plasma placental growth factor(PLGF)levels and perinatal outcomes in patients with early-onset pre-eclampsia(EOPE).Methods Fasting venous blood was collected from 138 EOPE patients on the day of delivery to detect PLGF levels.67 patients with PLGF levels≤12 pg/ml were regarded as low PLGF group,and 71 patients with PLGF levels>12 pg/ml were regarded as high PLGF group.The perinatal outcomes(gestational week of delivery,oligohydramnios,meconium stained amniotic fluid,small for gestational age)and newborn conditions[neonatal weight,neonatal 1 min Apgar score,lactic acid(LAC),blood glucose,blood calcium,hospitalization time in neonatal intensive care unit(NICU)]were recorded and compared between the two groups.Results The gestational week of delivery(35.43±1.39)weeks of high PLGF group was greater than that of low PLGF group(33.27±2.02)weeks,and the difference was statistically significant(P<0.05).The proportion of oligohydramnios,meconium stained amniotic fluid,small for gestational age of high PLGF group were 19.72%,30.99%and 15.49%,which were all lower than those of low PLGF group 41.79%,52.24%and 49.25%,and the difference was statistically significant(P<0.05).The neonatal weight(2635.25±412.07)g of high PLGF group were obviously higher than that of low PLGF group(1809.23±415.13)g,neonatal 1 min Apgar score(8.46±1.02)points,lactic acid(3.47±1.59)mmol/L,blood calcium(1.18±0.21)mmol/L,blood glucose(3.61±1.39)mmol/L were obviously better than those of low PLGF group(8.01±1.28)points,(6.03±2.79)mmol/L,(1.03±0.20)mmol/L,(3.17±1.20)mmol/L,and hospitalization time in NICU(10.12±9.47)d was obviously shorter than that of low PLGF group(16.73±9.85)d.The difference was statistically significant(P<0.05).Conclusion Plasma PLGF levels in EOPE patients have a certain value for evaluating perinatal outcomes and neonatal status.Patients with high-level PLGF have better perinatal outcomes and neonates than patients with low-level PLGF.