Bioengineered Corneas Grafted as Alternatives to Human Donor Corneas in Three High‐Risk Patients |
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Authors: | Oleksiy Buznyk Nataliya Pasyechnikova M. Mirazul Islam Stanislav Iakymenko Per Fagerholm May Griffith |
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Affiliation: | 1.Filatov Institute of Eye Diseases and Tissue Therapy of the, National Academy of Medical Sciences of Ukraine, Odessa, Ukraine;2.Integrative Regenerative Medicine Center, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden;3.Department of Neurosciences, Swedish Medical Nanoscience Center, Karolinska Institutet, Stockholm, Sweden |
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Abstract: | Corneas with severe pathologies have a high risk of rejection when conventionally grafted with human donor tissues. In this early observational study, we grafted bioengineered corneal implants made from recombinant human collagen and synthetic phosphorylcholine polymer into three patients for whom donor cornea transplantation carried a high risk of transplant failure. These patients suffered from corneal ulcers and recurrent erosions preoperatively. The implants provided relief from pain and discomfort, restored corneal integrity by promoting endogenous regeneration of corneal tissues, and improved vision in two of three patients. Such implants could in the future be alternatives to donor corneas for high‐risk patients, and therefore, merits further testing in a clinical trial. |
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Keywords: | collagen epithelium grafting patients remodeling transplantation |
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