他克莫司软膏联合口服药物递减疗法治疗女阴湿疹临床观察

目的 观察0.1%他克莫司软膏联合口服药物递减法治疗慢性女阴湿疹临床效果及复发率。方法 72例女阴湿疹患者,随机分为观察组与对照组,各36例。两组均口服复方甘草酸苷片及五维甘草那敏胶囊治疗,观察组外用他克莫司软膏,对照组外用地奈德乳膏。比较两组疗效、复发率及不良反应发生情况。结果 观察组治疗总有效率83.33%与对照组的72.22%比较,差异无统计学意义(P>0.05)。观察组复发率6.67%(2/30)低于对照组的26.92%(7/26),差异有统计学意义(P<0.05)。观察组不良反应发生率27.78%与对照组的16.67%比较,差异无统计学意义(P>0.05)。结论 0.1%他克莫司软膏联合口服药物治疗慢性女阴湿疹临床有效率高,安全性好,复发率低,可供临床借鉴。

Clinical observation of tacrolimus ointment combined with oral drug decremental therapy for female genital eczema

Objective To observe the clinical effect and recurrence rate of 0.1%tacrolimus ointment combined with oral drug decremental therapy for female genital eczema.Methods A total of 72 female patients with genital eczema were randomly divided into observation group and control group,with 36 cases in each group.Both groups received oral compound glycyrrhizin tablets and pentavitamin,licorice and chlorphenamine maleate capsules.The observation group was also treated by tacrolimus ointment externally,and the control group was also treated by desonide cream.The efficacy,recurrence rate and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment 83.33%of the observation group had no statistically significant difference compared with that of the control group 72.22%(P>0.05).The recurrence rate 6.67%(2/30)of the observation group was lower than that of the control group 26.92%(7/26),and the difference was statistically significant(P<0.05).The incidence of adverse reactions 27.78%of the observation group had no statistically significant difference compared with that of the control group 16.67%(P>0.05).Conclusion 0.1%tacrolimus ointment combined with oral drug decremental therapy shows high clinical effect for female genital eczema with high safety and low recurrence rate.It is worthy of clinical reference.