Design of Selective
PAK1 Inhibitor G-5555:
Improving Properties by Employing an Unorthodox Low-pKa Polar Moiety |
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| Authors: | Chudi O. Ndubaku,James J. Crawford,Joy Drobnick,Ignacio Aliagas,David Campbell,Ping Dong,Laura
M. Dornan,Sergio Duron,Jennifer Epler,Lewis Gazzard,Christopher E. Heise,Klaus P. Hoeflich,Diana Jakubiak,Hank La,Wendy Lee,Baiwei Lin,Joseph
P. Lyssikatos,Jasna Maksimoska,Ronen Marmorstein,Lesley J. Murray,Thomas O’Brien,Angela Oh,Sreemathy Ramaswamy,Weiru Wang,Xianrui Zhao,Yu Zhong,Elizabeth Blackwood,Joachim Rudolph |
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| Affiliation: | †Genentech,Inc., 1 DNA Way, South San Francisco, California 94080, United States;‡Afraxis,Inc., 6605 Nancy Ridge Road, Suite 224, San Diego, California 92121, United States;§ShanghaiChemPartner, 576 Libing Road, Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai 201203, PRC;∥Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, United States |
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| Abstract: | ![]()
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| Keywords: | Kinase inhibitor oncology hERG pKa |
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