Associations of vitamin B6 turnover rate with the risk of cardiovascular and all-cause mortality in hypertensive adults |
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| Institution: | 1. Department of Cardiology, Shaanxi Provincial People''s Hospital, Xi''an, Shaanxi, 710000, China;2. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China;3. Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China;4. Department of Cardiology, The Third Affiliated Hospital of Xi''an Jiaotong University, Xi''an, Shaanxi, 710000, China;5. Department of Intensive Care Unit, The Third People''s Hospital of Chengdu, 82 Qinglong Road, Chengdu, Sichuan, China;1. Department of Clinical Nutrition and Metabolism, Affiliated Zhongshan Hospital of Dalian University, Dalian, China;2. Department of Prevention and Healthcare, Affiliated Zhongshan Hospital of Dalian University, Dalian, China;3. Department of Medical Record and Statistics, Affiliated Zhongshan Hospital of Dalian University, Dalian, China;1. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China;2. Department of Pediatric, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210036, Jiangsu Province, China;3. Jiangsu Center for Safety Evaluation of Drugs, School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 210009, Jiangsu Province, China;4. Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou 215000, Jiangsu Province, China;5. Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, Jiangsu Province, China;1. Diabetes Unit, Endocrinology and Nutrition Department, Hospital Clínic, Barcelona, Spain;2. Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición. (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain;3. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain;4. Institut d''Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Barcelona, Spain;5. Endocrinology and Nutrition Department, Hospital Universitari Mútua de Terrassa, Terrassa, Spain;6. Endocrinology and Nutrition Department, Althaia University Health Network, Manresa, Spain;1. Department of Medicine, Division of Endocrinology and Metabolism, Western University, 268 Grosvenor Street, N6A 4V2, London, Ontario, Canada;2. Department of Epidemiology and Biostatistics, Western University, 1465 Richmond Street, N6G 2M1, London, Ontario, Canada;3. Centre for Diabetes, Endocrinology and Metabolism, St. Joseph''s Health Care London, 268 Grosvenor Street, N6A 4V2, London, Ontario, Canada;4. ICES Western, 800 Commissioners Road East, N6A 5W9, London, Ontario, Canada;5. Lawson Health Research Institute, 750 Base Line Road East, Suite 300, N6C 2R5, London, Ontario, Canada;6. Department of Medicine, Western University, 800 Commissioners Road East, N6A 5W9, London, Ontario, Canada;7. Department of Family Medicine, Western University, 1465 Richmond Street, N6G 2M1, London, Ontario, Canada;8. Department of Medicine, Division of Gastroenterology, Western University, 800 Commissioners Road East, N6A 5W9, London, Ontario, Canada;9. Department of Medicine, Division of Nephrology, Western University, 800 Commissioners Road East, N6A 5W9, London, Ontario, Canada;10. Schulich School of Medicine and Dentistry, Western University, 1151 Richmond Street, N6A 5C1, London, Ontario, Canada;1. Department of Clinical Medicine and Surgery, “Federico II” University, Naples, Italy;2. Division Impacts on Agriculture, Forests and Ecosystem Services (IAFES), Foundation Euro- Mediterranean Center on Climate Change (CMCC), Viterbo, Italy |
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| Abstract: | Background and aimThis study was to assess the association between vitamin B6 turnover rate and mortality in hypertensive adults.Methods and resultsVitamin B6 status including serum pyridoxal-5′-phosphate (PLP) levels, serum 4-pyridoxal acid (4-PA) levels, and vitamin B6 turnover rate (4-PA/PLP) were obtained from the 2005–2010 National Health and Nutrition Examination Survey (NHANES) dataset of hypertensive adults with follow-up through December 30, 2019. Using Cox proportional risk regression models, Hazard ratios (HRs) and 95% confidence intervals (CIs) were analyzed for PLP, 4-PA and 4-PA/PLP quartiles in relation to cardiovascular and all-cause mortality. A total of 5434 participants were included in this study (mean age, 58.48 years; 50.4% men), and the median 4-PA/PLP was 0.75. The median follow-up time was 11.0 years, with 375 and 1387 cardiovascular and all-cause deaths, respectively. In multivariate COX regression models, PLP was negatively associated with cardiovascular mortality (HR 95% CI] quartile 4 vs. 1: 0.66 0.47–0.94], Ptrend = 0.03) and 4-PA/PLP was positively associated with cardiovascular mortality (HR 95% CI] quartile 4 vs.1: 1.80 1.21–2.67], Ptrend = 0.01). Similarly, the higher the quartile of PLP, the lower the risk of all-cause mortality (HR 95% CI] quartile 4 vs. 1: 0.67 0.56–0.80], Ptrend < 0.01). The higher the quartile of 4-PA and 4-PA/PLP, the higher the risk of all-cause mortality (HR 95% CI] quartile 4 vs. 1: 1.22 1.01–1.48], Ptrend < 0.01; and 2.09 1.71–2.55], Ptrend < 0.01).ConclusionThe findings suggested that higher vitamin B6 turnover rate was associated with an increased risk of cardiovascular and all-cause mortality in hypertensive adults. |
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| Keywords: | Vitamin B6 Pyridoxal-5′-phosphate 4-Pyridoxic acid Vitamin B6 turnover rate Hypertensive Mortality |
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