High lipoprotein(a) levels and mitral valve disease: A systematic review |
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| Affiliation: | 1. Servicio de Cardiología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina;2. Servicio de Cardiología, Sanatorio Finochieto, Buenos Aires, Argentina;3. Facultad Medicina, Universidad FASTA. Mar del Plata, Argentina;4. Centro de Investigación en Endocrinología, Nutrición y Metabolismo (CIENM), Facultad de Ciencias de la Salud, Universidad Nacional de Formosa, Formosa, Argentina;1. Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy;2. Pediatric Diabetes and Metabolic Disorders Unit, Department of Surgical Sciences, Dentistry, Pediatrics and Gynaecology, University Hospital of Verona, Verona, Italy;3. Precision Medicine – Biological Resource Center, Transfusion Medicine, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico Milano, Milan, Italy;4. Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy;1. Department of Nutrition & Dietetics, School of Health Sciences & Education, Harokopio University, 70 Eleftheriou Venizelou Str., 17676 Athens, Greece;2. Center of Sleep Disorders, 1st Department of Critical Care and Pulmonary Services, Evangelismos Hospital, 45-47 Ipsilantou Str., 10676 Athens, Greece;1. Heart Failure Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing, China;2. Key Laboratory of Clinical Research for Cardiovascular Medications, National Health Committee, No.167 Beilishi Road, 10037, Beijing, China;1. School of Public Health, Faculty of Medicine, The University of Queensland, 266 Herston Rd, Herston, QLD 4006, Australia;2. UQ Poche Centre for Indigenous Health, Faculty of Health and Behavioural Sciences, The University of Queensland, 74 High Street, Toowong, QLD, 4066, Australia;3. Nutrition and Dietetics Department, Faculty of Public Health, Jimma University, Jimma, Ethiopia;4. The ARC Centre of Excellence for Children and Families Over the Life Course, The University of Queensland, 80 Meiers Road, Indooroopilly, QLD 4068, Australia;5. Faculty of Medicine, The University of Queensland, Princess Alexandra Hospital, Brisbane, Australia;6. College of Pharmacy and Nutrition, University of Saskatchewan, 107 Wiggins Rd, Saskatoon, SK, Canada;1. West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China;2. School of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, China;3. Chengdu Center for Disease Control and Prevention, Chengdu, China;4. School of Medicine, Tibet University, Lhasa, China;5. School of Public Health, Kunming Medical University, Kunming, China;6. Chongqing Center for Disease Control and Prevention, Chongqing, China;7. Tibet Center for Disease Control and Prevention, Lhasa, China;1. Department of Clinical Medicine and Surgery, “Federico II” University, Naples, Italy;2. Division Impacts on Agriculture, Forests and Ecosystem Services (IAFES), Foundation Euro- Mediterranean Center on Climate Change (CMCC), Viterbo, Italy |
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| Abstract: | AimsThe role of lipoprotein(a) [Lp(a)] as a possibly causal risk factor for atherosclerotic artery disease and aortic valve stenosis has been well established. However, the information available on the association between Lp(a) levels and mitral valve disease is limited and controversial. The main objective of the present study was to assess the association between Lp(a) levels and mitral valve disease.Data synthesisThis systematic review was performed according to PRISMA guidelines (PROSPERO CRD42022379044). A literature search was performed to detect studies that evaluated the association between Lp(a) levels or single-nucleotide polymorphisms (SNPs) related to high levels of Lp(a) and mitral valve disease, including mitral valve calcification and valve dysfunction. Eight studies including 1,011,520 individuals were considered eligible for this research. The studies that evaluated the association between Lp(a) levels and prevalent mitral valve calcification found predominantly positive results. Similar findings were reported in two studies that evaluated the SNPs related to high levels of Lp(a). Only two studies evaluated the association of Lp(a) and mitral valve dysfunction, showing contradictory results.ConclusionsThis research showed disparate results regarding the association between Lp(a) levels and mitral valve disease. The association between Lp(a) levels and mitral valve calcification seems more robust and is in line with the findings already demonstrated in aortic valve disease. New studies should be developed to clarify this topic. |
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| Keywords: | Lipoprotein(a) Mitral valve disease Mitral valve calcification Systematic review |
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