首页 | 本学科首页   官方微博 | 高级检索  
按 检索        


The association between a novel inflammatory biomarker,systemic inflammatory response index and the risk of diabetic cardiovascular complications
Institution:1. Department of Cardiology, Liaocheng People''s Hospital, Shandong University, Jinan, Shandong, 250012, PR China;2. Department of Cardiology, Liaocheng People''s Hospital Affiliated to Shandong First Medical University, Liaocheng, Shandong, 252000, PR China;3. Department of Nursing, Liaocheng Vocational & Technical College, Liaocheng, 252000, PR China;1. Department of Neurology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong First Medical University, Jinan, China;2. Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China;3. Department of Medical Genetics, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China;4. Shandong Laibo Biotechnology Co., Ltd, China;5. Department of Neurology, Tianyou Affiliated Hospital, Wuhan University of Science and Technology, Wuhan, China;6. Department of Neurology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China;7. Nursing Department, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong First Medical University, Jinan, China;8. School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China;1. Department of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, Beijing, China;2. Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China;3. Geriatric Department, Emergency General Hospital, Beijing, China;4. School of Medical and Health Sciences, Edith Cowan University, Perth, Australia;5. Center for Primary Health Care Research, Lund University/Region Skåne, Malmö, Sweden;1. Faculdade de Nutrição, Universidade Federal de Alagoas, Campus A. C. Simões, BR 104 Norte, Km 96,7, Tabuleiro dos Martins, CEP 57.072-970, Maceió, Alagoas, Brazil;2. Instituto de Química e Biotecnologia (IQB/UFAL), Universidade Federal de Alagoas, Campus A. C. Simões, BR 104 Norte, Km 96,7, Tabuleiro dos Martins, CEP 57.072-970, Maceió, Alagoas, Brazil;3. Rede Nordeste de Biotecnologia (RENORBIO), Universidade Federal de Alagoas, Campus A. C. Simões, BR 104 Norte, Km 96,7, Tabuleiro dos Martins, CEP 57.072-970, Maceió, Alagoas, Brazil;1. Department of Cardiology, Shaanxi Provincial People''s Hospital, Xi''an, Shaanxi, 710000, China;2. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China;3. Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China;4. Department of Cardiology, The Third Affiliated Hospital of Xi''an Jiaotong University, Xi''an, Shaanxi, 710000, China;5. Department of Intensive Care Unit, The Third People''s Hospital of Chengdu, 82 Qinglong Road, Chengdu, Sichuan, China
Abstract:Background and aimSystemic inflammatory response index (SIRI) is a novel inflammatory biomarker. The relationship between SIRI and the risk of diabetic cardiovascular complications is still unclear. The purpose of our study was to address the correlation between SIRI and the risk of cardiovascular diseases (CVD) in diabetes mellitus (DM) patients.Methods and resultsA total of 8759 individuals were selected from the National Health and Nutrition Examination Survey (NHANES) (2015–2020) in our study. Comparing with control (n = 6446) and pre-DM (n = 350) individuals, the DM patients (n = 1963) show the higher SIRI level (all P < 0.001) and prevalence of CVD (all P < 0.001). Furthermore, in a fully adjusted model, we observed the increase of tertiles of SIRI was a risk factor for CVD in DM patients (the middle tertile: 1.80, 95% CI: 1.13–3.13; the highest tertile: 1.91, 95% CI: 1.03–3.22; all P < 0.05), while the relationship between hypersensitive CRP (hs-CRP) and the risk of diabetic cardiovascular complications was not observed (all P > 0.05). Furthermore, the SIRI tertiles–CVD association was significant strongly in patients with high body mass index (BMI; >24 kg/m2) than in those with a low BMI (≤24 kg/m2, P for interaction = 0.045). Using restricted cubic splines, we observed a dose–response relation between lg SIRI and the risk of CVD in DM patients.ConclusionsThe elevated SIRI was independently associated with the increased risk of CVD in the DM population with a high BMI (>24 kg/m2), and its clinical value is greater than hs-CRP.
Keywords:SIRI  Diabetes mellitus  Complication  Cardiovascular disease  hs-CRP  DM"}  {"#name":"keyword"  "$":{"id":"pc_E3UaOCVEoG"}  "$$":[{"#name":"text"  "_":"diabetes mellitus  CVD"}  {"#name":"keyword"  "$":{"id":"pc_AIwEUuI7nG"}  "$$":[{"#name":"text"  "_":"cardiovascular diseases  SIRI"}  {"#name":"keyword"  "$":{"id":"pc_tnvrHYsznh"}  "$$":[{"#name":"text"  "_":"systemic inflammatory response index  hs-CRP"}  {"#name":"keyword"  "$":{"id":"pc_n1NoK8x49w"}  "$$":[{"#name":"text"  "_":"hypersensitive CRP  BMI"}  {"#name":"keyword"  "$":{"id":"pc_zqNm22aXgB"}  "$$":[{"#name":"text"  "_":"body mass index  FBG"}  {"#name":"keyword"  "$":{"id":"pc_vYxUCwpbbW"}  "$$":[{"#name":"text"  "_":"fasting blood glucose  HbA1C"}  {"#name":"keyword"  "$":{"id":"pc_aV3L2EpP5m"}  "$$":[{"#name":"text"  "_":"glycosylated hemoglobin A1c  HDL"}  {"#name":"keyword"  "$":{"id":"pc_7c9UQP6x1b"}  "$$":[{"#name":"text"  "_":"high-density lipoprotein  LDL"}  {"#name":"keyword"  "$":{"id":"pc_6NamoWDz5Y"}  "$$":[{"#name":"text"  "_":"low-density lipoprotein
本文献已被 ScienceDirect 等数据库收录！
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号