U-shaped association of serum uric acid with cardiovascular disease risk scores and the modifying role of sex among Chinese adults |
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| Affiliation: | 1. Department of Clinical Nutrition and Metabolism, Affiliated Zhongshan Hospital of Dalian University, Dalian, China;2. Department of Prevention and Healthcare, Affiliated Zhongshan Hospital of Dalian University, Dalian, China;3. Department of Medical Record and Statistics, Affiliated Zhongshan Hospital of Dalian University, Dalian, China;1. Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy;2. Pediatric Diabetes and Metabolic Disorders Unit, Department of Surgical Sciences, Dentistry, Pediatrics and Gynaecology, University Hospital of Verona, Verona, Italy;3. Precision Medicine – Biological Resource Center, Transfusion Medicine, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico Milano, Milan, Italy;4. Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy;1. Department of Cardiology, Shaanxi Provincial People''s Hospital, Xi''an, Shaanxi, 710000, China;2. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China;3. Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China;4. Department of Cardiology, The Third Affiliated Hospital of Xi''an Jiaotong University, Xi''an, Shaanxi, 710000, China;5. Department of Intensive Care Unit, The Third People''s Hospital of Chengdu, 82 Qinglong Road, Chengdu, Sichuan, China;1. Department of General Practice, University of Paris-Saclay, Paris, France;2. CESP (Centre for Research in Epidemiology and Population Health), Inserm U1018, Université Paris-Saclay, équipe soins primaires et prévention, Villejuif, France;3. Université de Paris, Paris, France; AP-HP, Service de Nutrition, Centre Spécialisé Obésité, Hôpital Européen Georges Pompidou, Paris, France;4. Institut National de la Santé et de la Recherche Médicale (INSERM), UMR 1153, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité, Paris, France;5. Inserm, Population-based Epidemiologic Cohorts Units, UMS 011, Villejuif, France;1. Human Nutrition & Exercise Research Centre, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK;2. Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia;3. School of Life Sciences, The University of Nottingham, Nottingham, UK;4. School of Population Health, Curtin University, Perth, Australia |
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| Abstract: | Background and aimsSerum uric acid (SUA) is involved in the development of cardiovascular disease (CVD). However, information on the dose-response relationship between SUA and CVD is limited in the Chinese population. This study aimed to investigate the potential nonlinear dose-response association of SUA with CVD risk in a Chinese population and to explore the effect of sex on these associations.Methods and resultsCross-sectional data, from 6252 Chinese adults aged 30–74 years who participated in the China Health and Nutrition Survey 2009, were stratified by SUA deciles. The 10-year risk of CVD was determined using the Framingham risk score. A restricted cubic spline (RCS) was incorporated into the logistic models to assess the nonlinear relationship between SUA and CVD. Among the participants, 65%, 20%, and 15% had low, moderate, and high 10-year CVD risks, respectively. Compared with the reference SUA strata of 225 to <249 μmol/L, CVD risk was significantly increased at SUA ≥294 μmol/L, with adjusted ORs ranging from 2.39 (1.33–4.33) to 4.25 (2.37–7.65). An increasingly higher nonsignificant CVD risk was found at SUA <225 μmol/L and showed a nonlinear U-shaped association. In the fitted RCS model, an approximate U-shaped association between SUA and CVD risk scores was found in women, but this significant nonlinear relationship was not found in men.ConclusionThis study showed that both lower and higher SUA levels were associated with a higher 10-year CVD risk among Chinese adults, forming a U-shaped relationship, and this pattern was particularly pronounced for women. |
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| Keywords: | Serum uric acid Cardiovascular disease U-shaped association Framingham risk score Restricted cubic spline China Health and nutrition survey |
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