Laser speckle imaging of intra organ drug distribution |
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| Authors: | Dmitry D Postnov Niels-Henrik Holstein-Rathlou Olga Sosnovtseva |
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| Affiliation: | 1.Department of Biomedical Sciences, Copenhagen University, Blegdamsvej 3, 2200 Copenhagen N, Denmark |
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| Abstract: | Laminar flow in arteries causes streaming and uneven distribution of infused agents within the organ. This may lead to misinterpretation of experimental results and affect treatment outcomes. We monitor dynamical changes of superficial cortical blood flow in the rat kidney following different routes of administration of the vasoconstrictor angiotensin II. Our analysis reveals the appearance of large scale oscillations of the blood flow caused by inhomogeneous intra organ drug distribution.OCIS codes: (120.6150) Speckle imaging, (170.1470) Blood or tissue constituent monitoring, (170.5380) Physiology |
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