| 丝裂素活化蛋白激酶在心肌细胞肥大中的作用 |
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| 引用本文： | 曾春雨,刘光耀.丝裂素活化蛋白激酶在心肌细胞肥大中的作用[J].第三军医大学学报,1998,20(4):311-313. |
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| 作者姓名： | 曾春雨 刘光耀 |
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| 作者单位： | 第三军医大学附属大坪医院心血管内科!重庆，400042 |
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| 摘 要： | 目的：研究神经肽Ｙ（ＮＰＹ）在高血压心肌细胞肥大中的作用。方法：复制腹主动脉狭窄和高盐摄入性高血压大鼠模型。测定对照组和高血压血浆、心肌ＮＰＹ水平和心肌丝裂素活化蛋白激酶（ＭＡＰＫ）活性。结果：高血压大鼠心重、ＮＰＹ水平和心肌ＭＡＰＫ活性均较显著高于对照组（Ｐ〈０．０５或Ｐ〈０．０１）。心肌ＭＡＰＫ活性与左心室肥大程度呈正相关（ｒ＝０．８０９，Ｐ〈０．０１）。结论：ＭＡＰＫ系统可能在ＮＰＹ致心肌细
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| 关 键 词： | 高血压 神经肽Y 心肌细胞肥大 MAPK |
Role of MAPK in hypertensive myocardial hypertrophy |
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| Zing Chunyu, Liu Guanyao, Wang Xukai, Yang Chengming, Wang Haowen.Role of MAPK in hypertensive myocardial hypertrophy[J].Acta Academiae Medicinae Militaris Tertiae,1998,20(4):311-313. |
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| Authors: | Zing Chunyu Liu Guanyao Wang Xukai Yang Chengming Wang Haowen |
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| Abstract: | Objective: To investigate the role of neuropeptide Y (NPY) in the pathogenesis of hypertensive myocardial hypertrophy. Methods: The study was carried out in rats in 2 groups, the hypertensive group induced with constriction of the abdominal aorta and taking high salt diet and the control. The NPY level in plasma and cardiac tissue and the activity of cardiac mitogen-activated protein kinase (MAPK) were measured. Results: Heart weight, NPY levels and MAPK activity were significantly elevated in the hypertensive rats (P <0. 05 to 0.01 ). There was a positive correlation of myocardial MAPK activity to left ventricular hypertrophy (r= 0. 809, P <0.01 ). Conclusion: MAPK system is possible involved in the pathophysiology of hypertensive myocardial hypertrophy induced by NPY. |
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| Keywords: | hypertension neuropeptide Y myocardial hypertrophy mitogen-activated protein kinase rat |
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