Noradrenaline inhibits central serotonin release through alpha2-adrenoceptors located on serotonergic nerve terminals |
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Authors: | Maura Guido Gemignani Anita Raiteri Maurizio |
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Affiliation: | (1) Instituto di Farmacologia e Farmacognosia, Università di Genova, Via Capo S. Chiara 5, I-16146 Genova, Italy |
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Abstract: | Summary The effect of noradrenaline on the depolarization-evoked release of 3H-5-hydroxytryptamine was investigated in superfused synaptosomes prepared from rat cortex and hippocampus and prelabelled with the radioactive indoleamine. Noradrenaline reduced in a concentration-dependent way the release of 3H-5-hydroxytryptamine elicited by 15 mM KCl. The inhibition was counteracted by the alpha-adrenoceptor antagonists phentolamine or yohimbine, but not by prazosin. The results indicate that, in rat brain, the inhibition of 5-hydroxytryptamine release by noradrenaline is mediated by adrenoceptors of the alpha2-type localized on the terminal serotonergic fibres. |
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Keywords: | Alpha2-Adrenoceptors Presynaptic receptors 5-Hydroxytryptamine release Noradrenaline Superfused synaptosomes |
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