| NMDA体内抗肿瘤作用的试验研究 |
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| 引用本文： | 叶建新,张 敏,仲来福.NMDA体内抗肿瘤作用的试验研究[J].大连医科大学学报,2000,22(2):98-100. |
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| 作者姓名： | 叶建新 张 敏 仲来福 |
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| 作者单位： | 大连医科大学卫生学教研室,辽宁大连,116027 |
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| 摘 要： | 目的：旨在评价新铂类化合物Ｎ－烷基亚胺二乙酸二氨铂（Ⅱ）配合物（ＮＭＤＡ）体内抑瘤作用。方法：采用小鼠移植性腹水瘤和实体瘤模型，检测生命延长率或瘤重抑制率。结果显示：对小鼠移植性腹水瘤艾氏腹水癌有较高疗效，当剂量为７５ｍｇ／ｋｇ时，生命延长率达１１２．３％；当剂量为５０，７５ｍｇ／ｋｇ时，对小鼠移植性实体瘤Ｓ１８０的瘤重抑制率分别为３０．６％和４３．９％，对小鼠移植性实体瘤Ｇ４２２有轻微的抑制作用
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| 关 键 词： | NMDA 生命延长率 卡铂 体内抗肿瘤作用 |
| 文章编号： | 1000-5676(2000)02-0098-03 |
Investigation of antitumor efficacy of NMDA on transplanted tumors in mice |
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| YE Jian xin,ZHANG Min and ZHONG Lai fu.Investigation of antitumor efficacy of NMDA on transplanted tumors in mice[J].Journal of Dalian Medical University,2000,22(2):98-100. |
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| Authors: | YE Jian xin ZHANG Min and ZHONG Lai fu |
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| Institution: | YE Jian-xin
,ZHANG Min
,ZHONG Lai-fu
(Department of Hygiene, Dalian Medical University, Dalian 116027, China) |
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| Abstract: | To investigate antitumor efficacy of a new Pt coordination complex NMDA,the antitumor tests were made in mouse bearing tumor.The results showed that the increase in life span of ascites tumor beating mice was 112 3%at a dose of 75 mg/kg(ip).The growth of S 180 solid sarcoma was also significantly suppressed by ip NMDA.At the dose of 50 or 75 mg/kg(ip),the inhibition rates were 30 6 and 43 9%,respectively.These results indicate that NMDA is a potential antitumor drug. WT5HZ] |
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| Keywords: | NMDA increase in life span carboplatinum |
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