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| 饰胶蛋白聚糖的抗纤维化和抗肿瘤作用 | |
| 引用本文： | 马伟峰,谭毅,蔡绍晖,陈宏远,杜军,蔡绍皙. 饰胶蛋白聚糖的抗纤维化和抗肿瘤作用[J]. 生物医学工程学杂志, 2007, 24(1): 222-225 |
| 作者姓名： | 马伟峰 谭毅 蔡绍晖 陈宏远 杜军 蔡绍皙 |
| 作者单位： | 1. 重庆大学,生物工程学院,国家教育部生物力学与组织工程重点实验室,重庆,400044 2. 暨南大学,药学院,临床药理教研室,广州,510632 3. 中山大学,药学院,广州,510612 |
| 基金项目： | 国家自然科学基金;国家重点实验室基金 |
| 摘 要： | 饰胶蛋白聚糖（Decorin，DCN）属富含亮氨酸小分子蛋白多糖家族成员之一。大量证据表明：DCN通过结合并中和转化生长因子-β（TGF-β），干扰其与受体结合所致的胞外基质过度沉积，以产生抗纤维化和抑制疤痕形成的作用；DCN亦通过激活EGFR／MAPK／p21信号通路和抑制EGF—EGFR介导的促细胞增殖信号通路等机制，抑制肿瘤细胞增殖与转移。基于DCN以上两方面的生物活性，加之源于人体自身产生，其重组产品免疫原性较低，提示DCN对于慢性纤维化和肿瘤等疾病的防治具有潜在的药用开发价值。 |
| 关 键 词： | 饰胶蛋白聚糖 表皮生长因子受体 抗纤维化 抗肿瘤 |
| 修稿时间： | 2004-09-092005-01-18 |
The Action of Decorin in Anti-fibrosis and Anti-cancer |
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| Ma Weifeng,Tan Yi,Cai Shaohui,Chen Hongyuan,Du Jun,Cai Shaoxi. The Action of Decorin in Anti-fibrosis and Anti-cancer[J]. Journal of biomedical engineering, 2007, 24(1): 222-225 | |
| Authors: | Ma Weifeng Tan Yi Cai Shaohui Chen Hongyuan Du Jun Cai Shaoxi |
| Affiliation: | Key Laboratory for Biomechanics & Tissue Engineering of the State Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China. |
| Abstract: | Decorin (DCN) is a member of the small leucine-rich proteoglycan gene family. Many studies indicated that DCN inhibited fibrosis and scar-formation by neutralization of TGF-P and interfering the binding of TGF-beta with its receptor, which induced ectopic deposition of extracellular matrix. Additionally, DCN can prevent the proliferation and metastasis of tumor cells by activating EGFR/MAPK/p21 signal pathway and inhibiting the cell proliferation pathway mediated by EGF-EGFR. It is suggested that the recombinant DCN had potential pharmaceutical potency in treatment of chronic fibrosis and neoplasm for its critical biological activities and low immunogenicity. |
| Keywords: | Decorin Epidermal growth factor receptor(EGFR) Anti-fibrosis Anti-cancer |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |