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| 蝮蛇毒中类狼疮抗凝蛋白体内抗凝作用的研究 | |
| 引用本文： | 杨斌,黎肇炎,陈美芳,班建东,黄君度,林发全. 蝮蛇毒中类狼疮抗凝蛋白体内抗凝作用的研究[J]. 广西医科大学学报, 2000, 17(2): 173-175 |
| 作者姓名： | 杨斌 黎肇炎 陈美芳 班建东 黄君度 林发全 |
| 作者单位： | 1. 广西医科大学药理学教研室,南宁,530021 2. 广西医科大学蛇毒研究所 3. 广西医科大学附属第一医院检验科 |
| 摘 要： | 目的：从中国产蝮蛇毒中分离纯化电泳纯度的类狼疮抗凝蛋白，研究其对动物体内的抗凝作用及机制。方法：测定蝮蛇毒中类狼疮抗凝蛋白对新西兰白兔的活化部分凝血活酶时间、凝血酶原时间和凝血酶时间的影响；对小鼠凝血时间的影响；对大鼠静脉血栓和血小板聚集功能的影响，以及类狼疮抗凝蛋白的溶血性试验。结果：类狼疮抗凝蛋白能显著地延长活化部分凝血活酶时间和凝血时间，明显地抑制静脉血栓的形成，无溶血作用。结论：类狼疮抗凝 |
| 关 键 词： | 蝮蛇毒 类狼疮抗凝蛋白 抗凝作用 |
| 修稿时间： | 2000-01-08 |
THE ANTICOAGULANT EFFECT OF LUPUS ANTICOAGULANT-LIKE PROTEIN FROM AGKI STRODON HALYS BREVICAUDUS VENOM IN VIVO |
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| Yang Bin,Li Zhaoyan,Chen Meifang,et al. THE ANTICOAGULANT EFFECT OF LUPUS ANTICOAGULANT-LIKE PROTEIN FROM AGKI STRODON HALYS BREVICAUDUS VENOM IN VIVO[J]. Journal of Guangxi Medical University, 2000, 17(2): 173-175 | |
| Authors: | Yang Bin Li Zhaoyan Chen Meifang et al |
| Abstract: | Objective:To study anticoagulant effect and mechanism of Lupus anticoagulant like protein(LALP),an electrophoresis purity LALP purified by ion exchange and gel filtraration chromatography from agkistrodon halys brevicaudus Methods:To measure prothrombin time (PT),activated partial thromboplastin time (APTT),thrombin time (TT);clotting time (CT);venous thrombosis and platelet aggregation in the presence of LALP in rabbit;mice;rat,respectively Results:It was showed that APTT and CT in the presence of LALP were markedly prolonged,the formation of venous thrombosis was obviously prevented without any hemolyzation Conclusion:LALP has anticoagulant effect in vivo,and the effective mechanism may interfere with phosphatide |
| Keywords: | agkistrodun venom lupus anticoagulant like protein anticoagulant |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |