葛根素聚氰基丙烯酸丁基酯纳米粒的制备及质量评价

目的：制备葛根素聚氰基丙烯酸正丁酯纳米粒（P-PBCA）,并对其进行质量评价.方法：以包封率和载药量为指标,采用正交设计综合评分法优化P-PBCA处方.结果：最佳工艺为葛根素质量20 mg、氰基丙烯酸正丁酯体积分数0.6％,pH为2.0,优化所得P-PBCA为球状,包封率为（78.13±7.42）％,载药量为（15.05±2.38）％;粒径（145.2±22.4） nm,Zeta电位（-28.7±1.1）mV.结论：正交设计综合评分法可用于P-PBCA的制备.

Preparation and Quality Evaluation of Puerarin Polybutylcyanacrylate Nanoparticles

ABSTRACT Objective: To prepare puerarin polybutylcyanacrylate nanoparticles (P PBCA) and evaluate the quality. Methods:Encapsulation efficiency and drug loading as the indices, a comprehensive scoring method of orthogonal design was used to optimize the formula of P-PBCA. Results:The optimum preparation technology was as follows: the amount of puerarin was 20mg, the volume fraction of BCA was 0.6%, and the pH value was 2.0. P-PBCA showed spherical shape with the encapsulation efficiency of (78.13±7.42)%, drug loading of (15.05±2.38)%, particle size of (145.2±22.4) nm and Zeta potential of (-28.7±1.1)mV. Conclusion:Comprehensive scoring method of orthogonal design is suitable for the optimization of P PBCA formula.