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黄根片对四氯化碳致大鼠慢性肝损伤的影响
引用本文:黄若干,何飞,覃佩莉,苏华,韦韡,曾宪彪,黄平权,韦保伟,韦桂宁.黄根片对四氯化碳致大鼠慢性肝损伤的影响[J].中国药师,2014(8):1285-1288.
作者姓名:黄若干  何飞  覃佩莉  苏华  韦韡  曾宪彪  黄平权  韦保伟  韦桂宁
作者单位:广西盈康药业有限责任公司 南宁530023,;广西中医药研究院药理研究所;广西盈康药业有限责任公司 南宁530023,;广西中医药研究院药理研究所;广西中医药研究院药理研究所;广西中医药研究院药理研究所;广西中医药研究院药理研究所;广西中医药研究院药理研究所;广西中医药研究院药理研究所
基金项目:南宁市科学研究与技术开发计划项目(编号:201106050C);广西科学研究与技术开发计划项目(编号:桂科攻1355004-6)
摘    要:目的:探讨黄根片对大鼠慢性肝损伤的防治作用.方法:50只Wistar大鼠随机分为空白对照组、模型组、阳性对照组(联苯双酯滴丸,0.2 g·kg-1)、黄根片高、低剂量(36 g·kg-1,9 g·kg-1)组.除空白对照组外,其余各组大鼠每周2次皮下注射四氯化碳复制慢性肝损伤模型,同时每天灌胃给药1次,连续12周,观察黄根片对慢性肝损伤大鼠血液生化指标以及肝组织病理变化的影响.结果:与空白对照组比较,模型组大鼠造模后12周体质量、残留肝组织百分率显著降低,肝脏系数、肝组织Hyp含量、血清ALT、AST含量显著升高,血清TP、Alb含量显著降低(P<0.05或0.01).与模型组比较,黄根片高、低剂量组灌胃给药12周能够显著提高大鼠血清TP含量和残留肝组织百分率(P<0.05).结论:黄根片对四氯化碳致大鼠慢性肝损伤模型有一定的保护作用.

关 键 词:黄根片  四氯化碳  慢性肝损伤
收稿时间:3/5/2014 12:00:00 AM
修稿时间:6/3/2014 12:00:00 AM

Effect of Huanggen Tablets on Chronic Hepatic Injury Induced by Carbon Tetrachloride in Rats
Huang RuoganGuining,He Fei,Qin Peili,Su Hu,Wei Wei,Zeng Xianbiao,Huang Pingquan,Wei Baowei and Wei Guining.Effect of Huanggen Tablets on Chronic Hepatic Injury Induced by Carbon Tetrachloride in Rats[J].China Pharmacist,2014(8):1285-1288.
Authors:Huang RuoganGuining  He Fei  Qin Peili  Su Hu  Wei Wei  Zeng Xianbiao  Huang Pingquan  Wei Baowei and Wei Guining
Institution:Huang Ruogan He Fei Qin Peili Su Hua Wei Wei ,Zeng Xianbiao, Huang Pmgquan, Wei Baowci ,Wei Guining ( 1. Guan- gxi Yingkang Pharmacy Co. , Ltd. , Nanning 530023, China; 2. Department of Pharmacology of Guangxi Institute of Chinese Medicine & Pharmaceutical Science)
Abstract:Objective: To investigate the effects of Huanggen tablets on chronic hepatic injury induced by carbon tetrachloride (CC14) in rats. Methods: Totally 50 male Wistar rats were randomly divided into normal goup, model group, bifendate pills group ( positive control group, 0.2 g · kg - 1 ), high dosage Huanggen tablets group ( 36 g · kg - 1 ) and low dosage Huanggen tablets group ( 9 g · kg-1 ) . The hepatic chronic injury model was induced by subcutaneous administration of CC14 twice a week for twelve weeks, and then the rats were given Huanggen tablets once a day. After the 12-week administration, biochemical indicators and the histopathology of liver were observed. Results: Compared with those in the normal group, the liver index, serum concentrations of ALT, AST, ALP and HYP in liver were significantly higher, while the percentage of residual liver tissue the serum concentrations of TP and ALB were significantly lower in the model group. Compared with the model group, high and low dosage Huanggen tablets groups could increase the serum concentration of TP and the percentage of residual liver tissue, and improve the pathologic change of hepatic tissue in rats sig- nificantly. Conclusion: Huanggen tablets have significantly protective functions in rats with chronic liver injury.
Keywords:Huanggen tablets  Carbon tetrachloride  Chronic hepatic injury
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