比较硬膜外阻滞复合安氟醚或异氟醚对肝血流及氧代谢的影响

目的 探讨硬膜外阻滞与安氟醚或异氟醚吸入复合麻醉对血流动力学，肝血流及代谢的影响。方法 选用健康杂种犬２０只行胸段硬膜外阻滞后分为两缚，分别吸入，０．５和１．０ＭＡＣ安氟醚或异氟醚，监测麻醉前后体循环，肝动脉，门静脉血流动力及肝脏氧供，氧耗。结果 硬膜外阻滞后血压，门静脉血流和氧供下降，加吸安氟醚０．５ＭＡＣ使心排血量也下降，１．０ＭＡＣ后肝动脉血流及氧供也减少，加吸异氟醚０．５ＭＡＣ心排血量稳定

The effects of epidural block combined with enflurane or isoflurane inhalation on hepatic blood flow and oxygen metabolism

Objective To explore the effects of epidural block combined with enflurane or isoflurane inhalation on hemodynamics and hepatic blood flow and oxygen delivery and consumption Methods Systemic and hepatic hemodynamics,oxygen delivery and consumption were studied in 20 healthy mongrel dogs anesthetized with epidural block combined with 0 5 or 1 0 MAC of either enflurane (n=10) or isoflurane (n=10) inhalation Results MAP,portal vein blood flow and oxygen delivery decreased significantly after epidural block Combined with 0 5 MAC enflurane CO decreased,with 1 0 MAC enflurane hepatic artery blood flow and oxygen delivery decreased too CO was not changed significantly by combined epidural block with 0 5 MAC isoflurane,and hepatic artery blood flow and oxygen delivery did not decrease significantly after 1 0 MAC isoflurane combined with epidural block The changes of HR,MAP,portal vein blood flow and oxygen delivery,hepatic oxygen consumption were similar in two groups Conclusion Epidural block combined with isoflurane inhalation causes less significant disturbance of systemic and hepatic hemodynamics and oxygen delivery than combined with enflurane