| 巴曲酶复合低温对全脑缺血再灌注期间ATP酶活性的影响 |
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| 引用本文： | 张林,曾因明,陈群. 巴曲酶复合低温对全脑缺血再灌注期间ATP酶活性的影响[J]. 中华麻醉学杂志, 1999, 19(6): 358-360 |
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| 作者姓名： | 张林 曾因明 陈群 |
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| 作者单位： | 徐州医学院江苏省麻醉学重点实验室!青岛大学医学院附属医院麻醉科(张林)，徐州医学院江苏省麻醉学重点实验室(曾因明，陈群) |
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| 摘 要： | 目的 观察低温，巴英酶及巴曲酶复合低温对沙土鼠全脑缺血后海马组织Ｎａ＾＋－Ｋ＾＋－ＡＴＰ酶，Ｃａ６２＋－ＡＴＰ酶活性的影响。方法 利用沙土鼠全脑缺血模型，观察全脑缺血１０分及再灌２０分，６０分时，低温，巴曲酶及巴曲酶复合低温对海马组织Ｎａ＾＋－Ｋ＾＋－ＡＴＰ酶，Ｃａ＾２＋－ＡＴＰ酶活性的影响。
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| 关 键 词： | 再灌注损伤 毒蛇凝血酸 低温 巴曲酶 ATP酶活性 |
Effect of batroxobin combined with hypothermia on ATPase activity during global isechmia reperfusion |
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| ZHANG Lin,ZENG Yinming,CHEN Qun Jiangsu Province Key Lab of Anesthesiology,Affiliated Hospital of Xuzhou Medical College,Xuzhou. Effect of batroxobin combined with hypothermia on ATPase activity during global isechmia reperfusion[J]. Chinese Journal of Anesthesilolgy, 1999, 19(6): 358-360 |
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| Authors: | ZHANG Lin ZENG Yinming CHEN Qun Jiangsu Province Key Lab of Anesthesiology Affiliated Hospital of Xuzhou Medical College Xuzhou |
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| Affiliation: | ZHANG Lin,ZENG Yinming,CHEN Qun Jiangsu Province Key Lab of Anesthesiology,Affiliated Hospital of Xuzhou Medical College,Xuzhou 221002 |
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| Abstract: | Objective To investigate the effect of hypothermia,batroxobin and batroxobin combined hypothermia on the activity of Na K ATPase and Ca 2 ATPase in hippocampus tissues after cerebral ischemia in rats Methods The cerebral ischemia of rats,produced by occluding both carotid arteries,were treated with hypothermia,batroxobin or batroxobin combined with hypothermia The values of Na K ATPase and Ca 2 ATPase activity in hippocampus tissues were measured with enzyme assay method 10min after total cerebral ischemia,20min and 60min after reperfusion Results Comparing with controlled values,the Na K ATPase and Ca 2 ATPase activity decreased significantly 10min after total cerebral ischemia (P<0 01),which were higher in hypothermia group than normothermia group at each time point (P<0 01) The ATPase activity values were higher in batroxobin combined with hypothermia group than single hypothermia or single batroxobin group (P<0 05) Conclusion Batroxobin combined with hypothermia may improve the recovery of ATPase activity during reperfusion after cerebral ischemia, the effect of which is much more better than single hypothermia or single batroxobin therapy |
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| Keywords: | Reperfusion injury Reptilase Hypothermia Na( ) K( ) exchanging ATPase Ca(2 ) transporting ATPase |
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