| 五种药物对兔脊髓的神经毒性实验研究 |
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| 引用本文： | 黄青青,思永玉,万林骏. 五种药物对兔脊髓的神经毒性实验研究[J]. 中华麻醉学杂志, 1999, 19(6): 355-357 |
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| 作者姓名： | 黄青青 思永玉 万林骏 |
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| 作者单位： | 昆明医学院第二附属医院SICU |
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| 摘 要： | 目的 对硬膜外术后镇痛用药是否对脊髓有神经毒性进行研究，以指导临床用药。方法 健康家兔４８只，硬膜外穿刺成功后，随机分为６组，每组８只，生理盐水对照组，布比卡因组，芬太尼组，曲巴多，氟哌利多，咪在唑仓组。６组均给药２次／ｄ，间隔１２小时，连续给药３天，继续观察至第７天处死兔作光交易和电镜检查。
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| 关 键 词： | 硬膜外镇痛 神经毒性 布比卡因 芬太尼 曲马朵 |
Experimental study of toxicities in rabbit spinal neurons of 5 drugs |
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| HUANG Qingqing,SI Yongyu,WAN Linjun,et al. Experimental study of toxicities in rabbit spinal neurons of 5 drugs[J]. Chinese Journal of Anesthesilolgy, 1999, 19(6): 355-357 |
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| Authors: | HUANG Qingqing SI Yongyu WAN Linjun et al |
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| Affiliation: | HUANG Qingqing,SI Yongyu,WAN Linjun,et al Department of Anesthesiology,2nd Affiliated Hospital,Kunmimg Medical College,Yunnan 650101 |
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| Abstract: | Objective To determine the pathologic effects of 5 kinds of widespreadly used drugs (bupivacaine,fentanyl,droperidol,tramadol,midazolam) on spine cord Methods After successive 3 day epidural administration of the drugs and a 3 day observation,the rabbits were killed and the spinal cord was examined under optical and electron microscope Results Serious damages of neuron were found in 2 animal from group droperidol and 1 from group midazolam under optical microscope Some reversible changes were found in all groups under electron microscope Conclusion Epidural administration of clinical dosage of bupivacaine,fentanyl,or tramadol is safe The long term neurotoxicity of droperidol and midazolam may occur |
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| Keywords: | Analgesia epidural Neurotoxicity Bupivacaine Fentanyl Droperidol Tramadol Midazolam |
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