肺癌患者染色体稳定性及诱变剂敏感性的研究

目的 探讨细胞染色体不稳定性与肺癌的关系。方法 采用微量全血培养法对２４例经病理证实但未治疗的原发性肺癌患者、２０例非癌性患者和２０名健康志愿者外周血淋巴细胞（ＰＢＬ）进行自发和诱发的染色体畸变和微核检测。结果人肺癌患者ＰＢＬ自发及诱发染色体畸变率和微核率明显高于非癌性肺病患者和健康者；肺癌患者具有较高的染色体畸变率和微核率。肺癌患者染色体稳定性较差。结论 细胞染色体稳定性评价对肺癌的早期诊断、鉴

Study of Chromosomal Instability and Mutagen Susceptibility of the Peripheral Blood Lymphocytes in Patients with Primary Lung Cancer

Objective To investigate the relationship between chromosomal instability and the development of the primary lung cancer.Methods The peripheral blood lymphocytes from 24 primary lung cancer patients,20 benign pulmonary disease patients and 20 healthy volunteers were cultured in vitro,the spontaneous,Mytomycin and Bleomycin induced chromosomal aberration rates and micronucleus rates were analyzed.Results The spontaneous, mutagen induced chromosomal aberration rate and micronucleus rate were significantly higher in primary lung cancer patients than in benign pulmonary diseases patients and normal individuals.The chromosome is unstable in patients with primary lung cancer.Conclusion The analysis of chromosomal instability may be useful in diagnosis,differential diagnosis of lung cancer,or in screening cancer susceptible population.