| 胃癌及胃粘膜不典型增生中Fas蛋白表达及其意义 |
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| 引用本文： | 陈杰 钱可大. 胃癌及胃粘膜不典型增生中Fas蛋白表达及其意义[J]. 实用癌症杂志, 2000, 15(1): 27-28 |
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| 作者姓名： | 陈杰 钱可大 |
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| 作者单位： | 浙江大学医学院附属第二医院 |
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| 摘 要： | 目的 探讨Ｆａｓ蛋白在胃癌形成与发展过程中作用及其意义。方法 采用免疫组化染色，对２０例正常胃粘膜，３８例胃粘膜不典型生，５２例胃癌进行Ｆａｓ蛋白检测。结果 胃粘膜不典型增生与胃癌的Ｆａｓ蛋白表达均显著高于正常胃粘膜（Ｐ均〈０．０５）。Ｆａｓ蛋白表达与胃癌分期，淋巴结转移无相关性。结论 Ｆａｓ蛋白与胃癌形成有关，与胃癌进展无关。
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| 关 键 词： | 胃癌 胃粘膜 不典型增生 Fas蛋白 |
Expression of Fas Protein in Gastric Carcinoma and Gastric Epithelial Dysplasia and Its Significance |
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| CHEN Jie,QIAN Ke da,ZHAO Chang jun,et al.. Expression of Fas Protein in Gastric Carcinoma and Gastric Epithelial Dysplasia and Its Significance[J]. The Practical Journal of Cancer, 2000, 15(1): 27-28 |
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| Authors: | CHEN Jie QIAN Ke da ZHAO Chang jun et al. |
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| Affiliation: | CHEN Jie,QIAN Ke da,ZHAO Chang jun,et al. Department of Medicine,second Hospital,Zhejiang Medical University,Hangzhou,310009 |
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| Abstract: | Objective In order to study the influence of Fas protein on gastric tumorigenesis and development.Methods Expression of Fas protein was observed in 20 cases of normal gastric mucosa,38 cases of gastric epithelial dysplasia(GED) and 52 cases of gastric carcinoma(GC) by immunohistochemical method.Results The expression rates of Fas protein in both GC and GED were significantly higher than that in normal gastric mumosa( P <0.05).No correlation between Fas expression and PT stage,lymph node status was observed.Conclusion Fas was involved in gastric tumorigenesis,but may not be related with gastvic carcinoma progression. |
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| Keywords: | Gastric carcinoma Gastric epithelial dysplasia Fas protein Apoptosis |
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