| 紫外分光光度法测定草酸右旋依地普仑片的溶出度 |
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| 引用本文： | 张丽霞,薛强.紫外分光光度法测定草酸右旋依地普仑片的溶出度[J].中国药房,2007,18(4):297-298. |
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| 作者姓名： | 张丽霞 薛强 |
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| 作者单位： | 河北唐山市工人医院药学部,唐山市,063000 |
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| 摘 要： | 目的:建立测定草酸右旋依地普仑片溶出度的方法。方法:采用紫外分光光度法在239nm波长处测定其吸收度,并计算回收率和溶出度。结果:草酸右旋依地普仑检测浓度在2.5~30μg.mL-1范围内与吸收度呈良好线性关系(r=0.9999),平均回收率为100.64%(RSD=0.49%);3批样品的30min溶出度均在90%以上。结论:本方法简便、准确,结果可靠,可用于草酸右旋依地普仑片的溶出度测定。
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| 关 键 词： | 草酸右旋依地普仑片 溶出度 紫外分光光度法 |
| 文章编号： | 1001-0408（2007）04-0297-02 |
| 收稿时间： | 2006-12-10 |
| 修稿时间： | 2006-12-30 |
Determination of the Dissolution of Escitalopram Oxalate Tablets by Ultraviolet Spectrophotometry |
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| ZHANG Lixia,XUE Qiang.Determination of the Dissolution of Escitalopram Oxalate Tablets by Ultraviolet Spectrophotometry[J].China Pharmacy,2007,18(4):297-298. |
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| Authors: | ZHANG Lixia XUE Qiang |
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| Abstract: | OBJECTIVE:To establish a method for the determination of the dissolution of escitalopram oxalate tablets.METHODS:The absorbability of escitalopram oxalate tablets was detected by ultraviolet spectrophotometry at a wavelength of 238nm,and the recovery and dissolution of which were calculated.RESULTS:The linear range of escitalopram oxalate tablets was 2.5～ 30μ g· mL-1(r=0.999 9),and its average recovery was 100.64%(RSD=0.49%).The dissolutions of 3 batches of samples were all above 90%.CONCLUSION:The method is simple,accurate,reliable,and suitable for the determination the dissolution of escitalopram oxalate tablets. |
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| Keywords: | Escitalopram oxalate tablets Dissolution UV spectrophotometry |
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