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痹肿消汤治疗活动期类风湿关节炎的临床研究
引用本文:梁清华,唐涛.痹肿消汤治疗活动期类风湿关节炎的临床研究[J].湖南医科大学学报,2000,25(5):449-452.
作者姓名:梁清华  唐涛
作者单位:附属湘雅医院中西医结合研究所,长沙
摘    要:对96例活动期类风湿关节炎(RA)病人采用痹肿消汤治疗与西药甲氨喋呤(MTX)作对照研究。结果表明:治疗一月,痹肿消汤组的病人其晨僵、关节疼痛、关节肿胀、关节压主关节功能障碍等主要症状与体征均较治前显著改善(P〈0.01或P〈0.05);而MTX组则无明显改善,两组比较差异有显著性(P〈0.01或P〈0.05)。治疗三月,上述主要症状与体征,两组均较治前有显著改善(P〈0.01或P〈0.05),但

关 键 词:类风湿性关节炎  痹肿消汤  甲氨喋呤  中医药疗法

Clinical investigation of effects of bizhongxiao decoction (BZX) on rheumatoid arthritis on active phase]
Q Liang,T Tang,H Zhang.Clinical investigation of effects of bizhongxiao decoction (BZX) on rheumatoid arthritis on active phase][J].Bulletin of Hunan Medical University,2000,25(5):449-452.
Authors:Q Liang  T Tang  H Zhang
Institution:Institute of Combined Traditional Chinese and Western Medicine, Hunan Medical University, Changsha 410008.
Abstract:Ninety-six patients with rheumatoid arthritis(RA) on active phase were divided into BZX-treated group(BZXG) and methotrexate-treated group(MTXG). The results showed that after 1-month treatment, symptoms and signs, such as joint tenderness, arthralgia, arthroncus, of patients in BZXG improved notably(P < 0.01 or P < 0.05), while those of patients in MTXG did not improve, there was significant difference between these two groups(P < 0.01 or P < 0.05). After 3-month treatment, these symptoms and signs improved in both groups(P < 0.01 or P < 0.05), but BZX had a better effect than MTX. ESR, CRP, RF, C3, IgG, IgA and IgM decreased significantly in both groups after treatment(P < 0.01 or P < 0.05), ESR, CRP in BZXG decreased more and faster than those in MTXG. In BZXG the obviously efficient rat was 70%, the total efficacy rate was 94%, while in MTXG was 52% and 87% respectively. It is indicated that BZX can improve symptoms and signs of patients with RA, has better and faster effects on acute phase reaction than MTX; and it has anti-immunologic effects similar to MTX, and has no obvious side effect.
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