|
|||||
|
|
| 慢性阻塞性肺疾病动物模型研究概况 | |
| 引用本文： | 高振,哈木拉提·吾甫尔,廖春燕. 慢性阻塞性肺疾病动物模型研究概况[J]. 国际病理科学与临床杂志, 2012, 32(2): 169-174 |
| 作者姓名： | 高振 哈木拉提·吾甫尔 廖春燕 |
| 作者单位： | 1. 新疆医科大学附属中医医院国家中医临床研究基地研究部,乌鲁木齐830000;新疆医科大学维吾尔医学系,乌鲁木齐830011 2. 新疆医科大学维吾尔医学系,乌鲁木齐,830011 3. 新疆医科大学附属中医医院国家中医临床研究基地研究部,乌鲁木齐,830000 |
| 基金项目： | 新疆名医名方与特色方剂学重点实验室开放课题 |
| 摘 要： | 慢性阻塞性肺病(chronic obstructive pulmonary disease,COPD)由基因-环境交互作用而致病,目前COPD拟临床研究大多是采用诱发性动物模型。动物选择根据实际需要以鼠、猪和灵长类动物为主。造模方法主要是将可诱发COPD的危险因素,强加于动物以诱导COPD的发生。造模时间的长短则与诱因的性质和暴露量密切相关。模型建成后主要从肺功能、肺部病理改变等方面,并采用血清炎症因子、细胞因子检测等手段对模型进行评价,但在实际操作中尚有待进一步的评估。 |
| 关 键 词： | 慢性阻塞性肺疾病 动物模型 机制 |
A review of chronic obstructive pulmonary disease model |
|
| GAO Zhen , Halmurat·UPUR , LIAO Chunyan. A review of chronic obstructive pulmonary disease model[J]. Journal of International Pathology and Clinical Medicine, 2012, 32(2): 169-174 | |
| Authors: | GAO Zhen Halmurat·UPUR LIAO Chunyan |
| Affiliation: | 1 (1.Research Department,Traditional Chinese Medicine Hospital Affiliated with Xinjiang Medical University & National Clinical Research Base of Traditional Chinese Medicine,Urumuqi 830000;2.Department of Uighur Medicine,Xinjiang Medical University,Urumuqi 830011,China) |
| Abstract: | Chronic obstructive pulmonary disease(COPD) is a genetic-environmental interaction disease;nowadays we use induced animal models to do clinical-mimetic research on COPD.The animals usually employed are rats,pigs and primates.The modeling methods aim to impose COPD-like risk factors on the animals.Duration of the modeling is closely coupled to the nature of the risk imposed and the type of exposure.We use lung function assays and lung pathological changes to identify fidelity of our COPD models.Other researchers,instead,use the serum levels of inflammatory factors and/or cytokines;these indices are still under evaluation. |
| Keywords: | chronic obstructive pulmonary disease animal model mechanism |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |