| MiR-146与免疫及自身免疫性疾病 |
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| 引用本文： | 杨明兰,顾卫琼. MiR-146与免疫及自身免疫性疾病[J]. 国际病理科学与临床杂志, 2012, 32(2): 165-168 |
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| 作者姓名： | 杨明兰 顾卫琼 |
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| 作者单位： | 上海市内分泌代谢病临床医学中心,上海市内分泌代谢病研究所,上海交通大学医学院附属瑞金医院内分泌科,上海200025 |
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| 基金项目： | 上海市科学技术委员会资助项目 |
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| 摘 要： | MicroRNAs (miRNAs)介导的基因表达对于维持正常的细胞周期、分化、增殖、凋亡以及维持免疫系统的稳定性方面发挥着非常重要作用.MiR-146家族包含miR-146a和miR-146b,在不同的造血细胞中具有不同的表达谱.研究发现miR-146与炎症、自身免疫性疾病密切相关,负性调节炎症和固有免疫反应,可作为...
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| 关 键 词： | miR-146 免疫 炎症 自身免疫性疾病 |
MiR- 146 in immunity and autoimmune diseases |
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| YANG Minglan , GU Weiqiong. MiR- 146 in immunity and autoimmune diseases[J]. Journal of International Pathology and Clinical Medicine, 2012, 32(2): 165-168 |
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| Authors: | YANG Minglan GU Weiqiong |
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| Affiliation: | (Shanghai Clinical Center for Endocrine and Metabolic Disease,Shanghai Institute of Endocrine and Metabolic Disease,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China) |
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| Abstract: | MiRNAs are now known to play important regulatory roles in a variety of cellular processes including cell cycle,differentiation,proliferation,and apoptosis.The miR-146 family includes miR-146a and miR-146b,with different expression spectrum in different hematopoietic cells.MiR-146 has a close relationship with inflammation and autoimmune diseases.Furthermore,miR-146 has been shown to play a role in the negative regulation of inflammatory and innate immune responses.It has a potential as a therapeutic target. |
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| Keywords: | miR-146 immunity inflammation autoimmune disease |
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