呼吸波振幅变化率评价麻杏石甘汤平喘作用初步研究

目的:建立生物信号采集系统分析、评价哮喘过程的新方法,以此观察麻杏石甘汤(MXSGT)的平喘作用。方法:采用生物信号采集系统记录豚鼠磷酸组胺引喘前后呼吸波的变化,并常规肉眼观察、记录其哮喘潜伏期、哮喘持续时间,根据肉眼观察结果,找出引喘后首次和末次抽搐波与正常呼吸波振幅变化率的特征差异,初步确定哮喘潜伏期和持续时间的判别标准;动物灌服MXSGT 5 d后,同法记录引喘30 min呼吸波,依据上述判别标准,分析MXSGT对动物哮喘潜伏期和持续时间的影响。结果:与正常呼吸波相比,首次和末次抽搐波平均振幅变化率分别为2465%和159%;MXSGT有较好的平喘作用,能延长哮喘潜伏期,缩短哮喘持续时间。结论:采用生物信号采集系统以呼吸波振幅变化率评价能较客观、规范地分析与评价哮喘指标,适用于观察药物的平喘作用。

Anti-asthmatic Effects of Maxing Shigan Decoction Based on Biological Signal Acquisition and Processing System

Objective:A new method was established to analyze and evaluate the progress of asthma based on the biological signal acquisition and processing system, which was used to observe the anti-asthmatic effects of Maxing Shigan decoction. Method: The biological signal acquisition and processing system was used to record the difference of breath wave before and after asthma induced by histamine phosphate, asthmatic latency and duration was recorded by the routine method at the same time, amplitude variations between the first or the last convulsive wave and the normal breath wave were determined according to the result observed by naked eye, then the diagnostic standard of asthmatic latency and duration were established preliminaryly. Breath wave of Guinea pigs was recorded 30 minute at the same way after Maxing Shigan decoction was gived for 5 days, influences of Maxing Shigan decoction in the asthmatic latency and duration were analyzed based on the above standard. Result: The average amplitude variation between the first or the last convulsive wave and the normal breath wave was 2 465% or 159%, Maxing Shigan decoction could delay the asthmatic latency and reduce the asthmatic duration, that showed that it had obvious anti-asthmatic effects. Conclusion: The anti-asthmatic effects of drugs can be observed objectively and standardly by the biological signal acquisition and processing system.