丙型肝炎患者血清肝功能与肝纤维化结果相关性探讨

[ 摘要 ] 目的 探讨肝功能指标：丙氨酸氨基转移酶（ALT）、白蛋白（ALB）、总胆红素（TBIL）在丙型肝炎患者肝纤维化评价中的应用。方法 检测106例丙型肝炎患者和79例健康体检人群的肝功能指标（ALT、ALB、TBIL）和肝纤维化标志物（HA、LN、PCⅢ、Ⅳ-C）的血清含量，并分析它们之间的关系。结果 丙型肝炎患者的血清HA、LN、PCⅢ、Ⅳ-C 、ALT、TBIL含量高于正常人组，ALB低于后者，差异具有统计学意义（P＜0.01）。相关分析表明：ALT与PCⅢ存在显著正相关（r＝0.201，P＜0.05）；ALB与HA、 PCⅢ、Ⅳ-C存在显著负相关（r＝-0.391，-0.239，-0.303，均P＜0.05）；TBIL与HA、LN、PCⅢ和Ⅳ-C存在显著正相关（r＝0.319，0.211，0.377，0.389，均P＜0.05）。结论 丙型肝炎患者的肝脏功能较正常人群有所下降，肝纤维化风险更高。肝功能指标ALT、ALB和TBIL在辅助诊断肝纤维化时有一定作用，三者在丙型肝炎患者肝纤维化评价中的应用价值呈TBIL > ALB >ALT顺序排列。

Study on the Correlation of Serum marker Between liver function and hepatic fibrosis in Patients with virus C Hepatitis

[ Abstract ] Objective To explore the role played by serum marker of liver function such as ALT,ALB and TBIL in the development of hepatic fibrosis in patients with C hepatitis. Methods Measure Serum ALT, ALB ,TBIL and HA, LN, PCIII , IV-C contents in 106 patients with virus C hepatitis and 79 healthy adults and analysis the relation of the serum marker. Results The serum levels of HA、LN、PCⅢ、Ⅳ-C、ALT、TBIL in patients with virus C hepatitis were significantly higher than those in the healthy, and ALB was lower than in the later (P<0.01).Correlationships among these markers were: ALT vs PCⅢ（r＝0.201，P＜0.05）；ALB vs HA、PCⅢ、Ⅳ（r＝-0.391，-0.239，-0.303，all P＜0.05）；TBIL vs HA、LN、PCⅢ and Ⅳ-C（r＝0.319，0.211，0.377，0.389，all P＜0.05）. Conclusions Patients with C hepatitis have decreased liver function and higher risk of hepatic fibrosis. ALT, ALB and TBIL played certain role in auxiliary diagnosis of hepatic fibrosis in patients with C hepatitis and the application value of them is TBIL > ALB > ALT.