| 95例艾滋病患者药物不良反应的分析 |
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| 引用本文： | 王芳,郜桂菊,孙娜,肖江,杨涤,张伟.95例艾滋病患者药物不良反应的分析[J].临床药物治疗杂志,2013(6):20-24. |
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| 作者姓名： | 王芳 郜桂菊 孙娜 肖江 杨涤 张伟 |
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| 作者单位： | [1]首都医科大学附属北京地坛医院感染中心北京100015 [2]首都医科大学附属北京地坛医院药剂科北京100015 |
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| 基金项目： | 十二五国家科技重大专项“中医药防治重大传染病临床科研基地与技术平台建设（2012ZX10005010-003） |
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| 摘 要： | 目的:分析95例艾滋病(AIDS)患者的药物不良反应发生情况及特点。方法:采用回顾性分析方法,对95例药物不良反应报告涉及的患者年龄、性别、用药情况以及不良反应事件等进行分类统计。结果:95例药物不良反应中男性79例,女性16例,2049岁之间82例;高效抗逆转录病毒治疗(HAART)药物不良反应发生率最高,占46.60%;临床表现以皮疹为主,其次为肝损伤;平均合并用药种类达15.46种。结论:AIDS患者个体情况特殊,易发生药物不良反应的因素较多,开展和加强药物不良反应监测,对保障此类患者的用药安全有重要意义。
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| 关 键 词： | AIDS 药物不良反应 用药安全 |
Analysis of adverse drug reactions in 95 AIDS patients |
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| Wang Fang,Gao Gui-ju,Sun Na,Xiao JiangI,Yang Di,Zhang Wei.Analysis of adverse drug reactions in 95 AIDS patients[J].Clinical Medication JOurnal,2013(6):20-24. |
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| Authors: | Wang Fang Gao Gui-ju Sun Na Xiao JiangI Yang Di Zhang Wei |
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| Institution: | 1 Infection Centre, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China; 2 Department of Phamacy, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China |
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| Abstract: | Objective： To analyze the occurrence and characteristics of the adverse drug reactions in AIDS patients in our hospital. Methods： The age, gender, medication and adverse events were retrospectively analyzed in 95 cases who had adverse drug reactions. Results： Of 95 cases, there were 79 male patients and 16 female patients,most were 20 to 49 years old. The highest incidence（46.60%） occurred in patients who used HAART drugs. Rash was the major clinical manifestation of adverse drug reaction, followed by liver injury. The average number of drug combination were up to 15.46. Conclusion： The individual conditions of AIDS patients are different from the others, which easily result in adverse drug reaction. It is important to develop and enhance adverse drug reaction monitoring, and to protect the drug safety for AIDS patients. |
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| Keywords: | AIDS Adverse drug reaction Drug safety |
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