Distinct regulation of genes by bFGF and VEGF-A in endothelial cells |
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Authors: | Jih Y J Lien W H Tsai W C Yang G W Li C Wu L W |
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Institution: | (1) Institute of Molecular Medicine, National Cheng Kung University Medical College, Tainan, 70101, Taiwan, ROC;(2) Department of Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan, ROC;(3) Institute of Molecular Medicine, National Cheng Kung University Medical College, 1, University Road, Tainan, 70101, Taiwan, ROC. Tel: |
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Abstract: | A finely tuned balance of angiogenic inhibitors and inducers controls the activity of angiogenesis characterized by proliferation,
migration and differentiation of endothelial cells. Among many angiogenic factors, basic fibroblast growth factor (bFGF) was
first identified to be angiogenic whereas vascular endothelial growth factor A (VEGF-A) is an endothelial cell specific mitogen.
In addition to being a specific mitogen, VEGF-A is also known as a vascular permeability factor. The majority of growth factors
transduce their mitogenic signals from cell surface to nucleus where gene expression occurs. Whether these ligands utilize
a distinct or a common molecular pathway to exert their biological effects on human endothelial cells remains elusive. We
thus studied the expression profile of 884 human genes under the influence of either bFGF or VEGF-A alone in the context of
human endothelial cells. A total of ninety-four genes were differentially regulated by more than two folds. The expression
patterns of 32 genes are similar between the treatment of either factor alone whereas those of the remaining 62 genes are
only regulated by one but not the other factor. Their function in the control of angiogenesis will be discussed and apoptotic
signaling in the regulation of angiogenesis is also implicated.
This revised version was published online in June 2006 with corrections to the Cover Date. |
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Keywords: | angiogenesis bFGF endothelial cells HUVEC microarray VEGF-A |
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