Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis |
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| Authors: | Baker Stephen J Zhang Yong-Kang Akama Tsutomu Lau Agnes Zhou Huchen Hernandez Vincent Mao Weimin Alley M R K Sanders Virginia Plattner Jacob J |
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| Affiliation: | Anacor Pharmaceuticals Inc., 1060 East Meadow Circle, Palo Alto, California 94303, USA. sbaker@anacor.com |
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| Abstract: | A structure-activity relationship investigation for a more efficacious therapy to treat onychomycosis, a fungal infection of the toe and fingernails, led to the discovery of a boron-containing small molecule, 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), which is currently in clinical trials for onychomycosis topical treatment. |
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