| 血红素加氧酶-1在肾脏疾病中的研究进展 |
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| 引用本文： | 欧阳南,刘晓城. 血红素加氧酶-1在肾脏疾病中的研究进展[J]. 国外医学:内科学分册, 2009, 36(9): 551-554,558 |
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| 作者姓名： | 欧阳南 刘晓城 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院肾内科,湖北,武汉,430030;华中科技大学同济医学院附属同济医院肾内科,湖北,武汉,430030 |
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| 摘 要： | 血红素加氧酶（HO）是血红素降解的起始酶和限速酶，其主要功能是代谢血红素成为一氧化碳、胆绿素及铁离子。HO—1是HO的一种同工酶，为诱导型HO。HO-1及血红素代谢产物具有抗炎、抗氧化、抗凋亡、扩张血管等生理作用。HO-1作为一种重要的应激蛋白，在急性肾脏损伤、肾小球肾炎、肾间质纤维化等肾脏疾病的病理生理发展过程中发挥着重要的保护作用，有效地调控其表达有可能成为预防和治疗相关疾病的新策略。
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| 关 键 词： | 血红素加氧酶-1 一氧化碳 胆红素 肾脏疾病 |
Research progress on heme oxygenase-1 in renal diseases |
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| OU-YANG Nan,LIU Xiao-cheng. Research progress on heme oxygenase-1 in renal diseases[J]. Foreign Medical Sciences(Section of Internal Medicine), 2009, 36(9): 551-554,558 |
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| Authors: | OU-YANG Nan LIU Xiao-cheng |
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| Affiliation: | OU-YANG Nan,LIU Xiao-cheng. Department of Nephrology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China |
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| Abstract: | Heme oxygenase(HO),which functions in metabolizing heme into carbon monoxide,biliverdin and ferri ion,is the initial enzyme and restriction enzyme in the degrative reaction of heme.HO-1 is an inducing HO,which is an isoenzyme of HOs.The physiological effects of HO-1 and the heme metabolite include anti-inflammation,anti-oxidation,anti-apoptosis,dilation of blood vessels,and etc.It is proved that HO-1 is an important stress-reactive protein,which dramatically increases and exerts cytoprotective action when t... |
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| Keywords: | Heme oxygenase-1 Carbon monoxide Bilirubin Renal diseases |
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