Effect of 5-Fluorouracil and UFT on Experimental Liver Metastasis Model of Colorectal Cancer Using Mouse Colon 26 Cells |
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| Authors: | Takeshi Tominaga Yoko Yoshida Goro Kosaki Minoru Kurihara |
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| Institution: | Department of Surgery, Tokyo Metropolitan Komagome Hospital, 3–18–22 Honkomagome, Bunkyo-ku, Tokyo 113;Department of Internal Medicine, Toyosu Hospital, Showa University School of Medicine, 4–1–18 Toyosu, Koto-ku, Tokyo 135 |
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| Abstract: | Effects of 5-fluorouracil (5-FU) and UFT on an experimental liver metastasis model were compared at equi-effective dosage levels against subcutaneous tumor of mouse colon 26. 5-FU at the dosage level of 40 mg/kg suppressed the subcutaneous tumor growth by 70.0% and 45.0% on day 13 and day 18, respectively, and UFT at 20 mg/kg provided almost equal suppression (63.0% and 48.0%). In the liver metastasis model, 5-FU at 40 mg/kg showed more potent prevention of the formation of metastatic foci (94.9%) than did UFT (60.4%) at 20 mg/kg. 5-FU at 40 mg/kg produced a much higher peak serum level of 5-FU than did UFT at 20 mg/kg and also showed a much higher AUC (area under the curve) level in the portal blood. These results suggest that oral administration of 5-FU might be useful in prevention of liver metastasis of colorectal cancer. |
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| Keywords: | Colorectal cancer Liver metastasis model Colon 26 5-FU UFT |
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