联合检测a—L-岩藻糖苷酶与甲胎蛋白对原发性肝癌的诊断价值

目的探讨联舍检测a-L-岩藻糖苷酶与甲胎蛋白对原发性肝癌的诊断价值。方法电化学发光和生化分析仪分别检测53例原发性肝癌患者甲胎蛋白（A即）和a—L-岩藻糖苷酶（AFU），45例乙型肝炎患者为阴性对照。结果原发性肝癌患者血清AFU活性显著增高（P〈0．05），AFP含量显著高于肝病组（P〈0．05）。血清AFU和AFP对原发性肝癌诊断的敏感性分别为73．6％和64．2％，特异性分别为82．2％和88．9％，联合检测AFU和AFP诊断的敏感性、特异性分别提高到77．4％、91．1％。患者术后血清AFU活性和AFP浓度显著降低，复发时两者再度升高。结论a—L-岩藻糖苷酶与甲胎蛋白联合检测可明显提高原发性肝癌诊断的敏感性和特异性，对患者预后及复发也具有指导意义。

Diagnostic value of combined detection of AFU and AFP in primary hepatic carcinoma

Objective To investigate the value of combined detection of serum AFU and AFP in the diagnosis of primary hepatic carcinoma （PHC）. Methods Serum AFP （with ECLIA） and AFrO （with Biochemistry Analyzer） levels were determined in 53 patients with PHC, and 45 eases of chomic bepatics as cotronl. Results The positive rates of AFU and AFP in cases with PHC were significantly higher than those in chornic hepatics （ P 〈 0.05, P 〈 0.05, respectively）. The diagnostic sensitivity of AFP and AFU for PHC were 73.6 %, 64.2 % respectively, and the specificity were 82.2%, 88.9% respectively. The sensitivity and specificity of combined examninafion of AFU and AFP were 77.4% and 91.1, respectively. The level of AFU and AFP decreased significantly after operation, and increased again when recurred. Conclusion Combined determination of AFU and AFP can raise the sensitivity and specificity in the diagnosis of PHC, and would be helpful in prognosis and recradesccnce.