慢性阻塞性肺疾病患者肺血气分析与糖尿病的相关性研究

目的 明确慢性阻塞性肺疾病(COPD)患者肺血气分析与糖尿病之间的关系对临床研究的意义.方法 选择COPD稳定期患者125例,其中合并糖尿病患者69例(试验组),单纯COPD患者56例(对照组),对两组患者进行血气分析以及肺功能指标的检测.结果 对照组患者肺通气功能指标用力肺活量(FVC)、肺活量(VC)、第1秒用力呼气容积(FEV1)、用力呼气中期流速(PEF)(25%～75%)、肺一氧化碳弥散量(DLCO)及肺一氧化碳弥散量实测值占预计值的百分比(DLCO/PRED)显著高于试验组,两组比较差异有统计学意义(P<0.05).试验组动脉血氧分压(PaO2)为(61.23±8.34)mmHg(1mmHg=0.133 kPa),较对照组的(72.34±9.32)mmHg有明显的降低趋势(P<0.05),而两组动脉血二氧化碳分压(PaCO2)比较差异无统计学意义(45.34±6.43)mmHg比(44.89±4.98)mmHg,P>0.05].结论 COPD合并糖尿病会导致患者肺通气功能和弥散功能受到一定的损害,在临床治疗中应当注意合理调整治疗方法.

Abstract：

Objective To study the correlation of blood gas analysis and diabetes mellitus in chronic obstructive pulmonary disease(COPD)patients and its clinical significance.Methods One hundred and twenty-five patients with stable phase COPD patients including 69 cages with COPD combined with diabetes mellitus(experimental group),56 patients with COPD alone(control group).The blood gas analysis and pulmonary function were detected.Results The simple pulmonary function forced vital capacity(FVC),vital capacity(VC),forced expired volume in one second(FEV1),peak expiratory flow (PEF)(25%-75%)and the diffusion function parameters diffusion capacity for carbon monoxide of the lung (DLCO),DLCO/PRED in control group were significantly higher than those in experimental group(P<0.05).Arterial partial pressure of oxygen(PaO2)was lower in experimental group than that in control group(61.23±8.34)mm Hg(1 mm Hg=0.133 kPa)vs.(72.34±9.32)mm Hg,P<0.05],while there was no significant difference in partial pressure of carbon dioxide in artery(PaCO2)between two groups(45.34±6.43)mm Hg vs.(44.89±4.98)mm Hg,P>0.05].Conclusion COPD combined with diabetes mellitus may lead to some damage in lung function and diffusion function,it should be noted in the clinieal treatment of reasonable adjustments in treatment.

Correlation study of blood gas analysis and diabetes mellitus in chronic obstructive pulmonary disease

Objective To study the correlation of blood gas analysis and diabetes mellitus in chronic obstructive pulmonary disease(COPD)patients and its clinical significance.Methods One hundred and twenty-five patients with stable phase COPD patients including 69 cages with COPD combined with diabetes mellitus(experimental group),56 patients with COPD alone(control group).The blood gas analysis and pulmonary function were detected.Results The simple pulmonary function forced vital capacity(FVC),vital capacity(VC),forced expired volume in one second(FEV1),peak expiratory flow (PEF)(25%-75%)and the diffusion function parameters diffusion capacity for carbon monoxide of the lung (DLCO),DLCO/PRED in control group were significantly higher than those in experimental group(P<0.05).Arterial partial pressure of oxygen(PaO2)was lower in experimental group than that in control group(61.23±8.34)mm Hg(1 mm Hg=0.133 kPa)vs.(72.34±9.32)mm Hg,P<0.05],while there was no significant difference in partial pressure of carbon dioxide in artery(PaCO2)between two groups(45.34±6.43)mm Hg vs.(44.89±4.98)mm Hg,P>0.05].Conclusion COPD combined with diabetes mellitus may lead to some damage in lung function and diffusion function,it should be noted in the clinieal treatment of reasonable adjustments in treatment.