Biorhythms of activities of liver and blood dehydrogenases and changes in body weight of the rats feeding normal diet or excess of sugar substitutes |
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Authors: | Yu A Petrovich A I Volozhin V A Zubtsov S M Kichenko |
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Institution: | (1) Moscow State Medical and Stomatological University, Russia;(2) All-Russia Institute for Mechanization of Flax Growing, Russian Academy of Agricultural Sciences, Tver |
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Abstract: | Biorhythms with higher levels of activity of sorbitol dehydrogenase and lactate dehydrogenase in blood plasma, specific activity
of sorbitol dehydrogenase, lactate dehydrogenase, and malate dehydrogenase in the liver, and body weight of rats were more
pronounced in the spring-summer period than in the autumn-winter period. These specific features were revealed in animals
feeding a normal diet or food with 54 and 27% sugar substitute sorbitol. However, specific activity of glucose-6-phosphate
dehydrogenase in the liver was higher in the autumn-winter period. Activity of sorbitol dehydrogenase in blood plasma increased
by tens of times due to induction of sorbitol synthesis (substrate) in the liver. Sugar substitute xylitol is structurally
similar to sorbitol, but is not the substrate for sorbitol dehydrogenase. However, the effect of xylitol on activities of
lactate dehydrogenase, malate dehydrogenase, and glucose-6-phosphate dehydrogenase in the spring-summer period was similar
to that of sorbitol.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 12, pp. 686–689, December, 2007 |
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Keywords: | dehydrogenases sorbitol xylitol sucrose |
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