Acylated triterpenoid saponins from Schima noronhae and their cell growth inhibitory activity |
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Authors: | Ohtsuki Takashi Miyagawa Takashi Koyano Takashi Kowithayakorn Thaworn Kawahara Nobuo Goda Yukihiro Ishibashi Masami |
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Institution: | Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan. |
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Abstract: | Two new acylated triterpenoid saponins were isolated from the branches of Schima noronhae by bioassay-guided purification. Their chemical structures were established on the basis of spectroscopic analysis and chemical means as 3-O-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-galactopyranosyl-(1-->3)-beta-D-glucopyranosyl-(1-->2)]-beta-D-glucuronopyranosyl 22-O-angeloyl-A1-barrigenol (1) and 3-O-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-galactopyranosyl-(1-->3)-beta-D-glucopyranosyl-(1-->2)]-beta-D-glucuronopyranosyl 22-O-angeloylerythrodiol (2). Compounds 1 and 2 showed cell growth inhibitory activity against both HeLa and DLD1 cells at a concentration of less than 10 microM. |
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