A case of atypical hemolytic uremic syndrome with a transient decrease in complement factor H |
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| Authors: | Hyewon Hahn Eun Young Um Young Seo Park Hae Il Cheong |
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| Affiliation: | (1) Department of Pediatrics, Eulji University School of Medicine, Daejeon, Korea;(2) Department of Pediatrics, Seoul National University College of Medicine, Clinical Research Institute, Seoul, Korea;(3) Department of Pediatrics, University of Ulsan College of Medicine, Ulsan, Korea;(4) Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea |
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| Abstract: | We report a case of sporadic atypical hemolytic uremic syndrome (HUS) with a transient decrease in complement factor H. Referred for hemolysis and azotemia without diarrhea prodrome, this 31-month-old boy showed a decreased complement 3 (C3) and complement factor H (FH) level. However, the factor H gene (HF1) mutation was missing. After the hemolysis was controlled with plasma infusion, the C3 and FH levels recovered. The patient s renal function fully recovered and remained normal, and there was no recurrence of the HUS. |
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| Keywords: | Complement 3 Complement factor H Hemolytic-uremic syndrome |
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