| 伊曲康唑纳米粒的制备及其在小鼠体内的分布 |
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| 引用本文： | 时晔,贺芬,黄冲,谈邹念. 伊曲康唑纳米粒的制备及其在小鼠体内的分布[J]. 中国医药工业杂志, 2010, 41(2) |
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| 作者姓名： | 时晔 贺芬 黄冲 谈邹念 |
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| 作者单位： | 上海医药工业研究院,药物制剂国家工程研究中心,上海,201203 |
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| 摘 要： | 用HPLC法测定了小鼠单剂量(20mg/kg)尾静脉注射伊曲康唑纳米粒及其市售注射剂后心、肝、脾、肺、肾、脑和血浆中的药物浓度.结果表明,伊曲康唑纳米粒在肺中的AUC为注射剂的32.94倍;在心、肾组织的蓄积量减少,在各组织中的半衰期延长,尤以肝、脾、肺为甚.说明伊曲康唑纳米粒的肺靶向性明显优于市售注射剂.
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| 关 键 词： | 伊曲康唑 纳米粒 注射剂 组织分布 |
Preparation and Distribution in Mice of Itraconazole Nanoparticles |
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| SHI Ye,HE Fen,HUANG Chong,TAN Zounian. Preparation and Distribution in Mice of Itraconazole Nanoparticles[J]. , 2010, 41(2) |
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| Authors: | SHI Ye HE Fen HUANG Chong TAN Zounian |
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| Abstract: | Itraconazole nanoparticles and its injection were injected intravenously with single dose of 20 mg/kg to mice.The drug concentrations in heart,liver,spleen,lung,kidney,brain and plasma were determined by HPLC.The results showed that the A UC in lung of prepared nanoparticles was 32.94 times as that of injection.Compared with the injection,the nanoparticles had less accumulation in heart and kidney and longer t_(1/2) in all tissues especially in liver,spleen and lung.It was indicated that the lung-targeted characteristic of nanoparticles Was superior to injection. |
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| Keywords: | itraconazole nanoparticles injiection tissue distribution |
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