Permanent alopecia following chemotherapy and bone marrow transplantation |
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Authors: | Tran D Sinclair R D Schwarer A P Chow C W |
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Institution: | Department of Dermatology, Alfred Hospital, Prahran, Australia. |
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Abstract: | Alopecia can be a psychologically daunting prospect for people requiring cancer chemotherapy. Fortunately, most patients experience only temporary hair loss. We report the case of a 23-year-old woman with chronic myeloid leukaemia who developed permanent, near-total alopecia of her scalp, eyebrows, eyelashes, axillary and public hair following busulphan and cyclophosphamide chemotherapy which was used as conditioning prior to allogeneic bone marrow transplantation. The histology from a scalp biopsy revealed hair follicle destruction. Topical minoxidil failed to induce significant re-growth. |
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Keywords: | busulphan cicatricial cyclophosphamide hair loss scarring telogen and anagen effluvium |
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