Docetaxel in the treatment of advanced non-small-cell lung cancer |
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Authors: | Saloustros Emmanouel Georgoulias Vassilis |
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Institution: | Department of Medical Oncology, University Hospital of Heraklion, Voutes 71110, Heraklion, Crete, Greece. georgsec@med.uoc.gr |
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Abstract: | Systemic chemotherapy provides improvement in both survival and quality of life for patients with advanced non-small-cell lung cancer (NSCLC). Docetaxel is the only agent currently approved for both first- and second-line treatment of advanced NSCLC. Multiple randomized clinical trials have established the efficacy of platinum-docetaxel regimens for the first-line treatment of advanced NSCLC. Carboplatin-based regimens and nonplatinum combinations with docetaxel also have proven efficacy in first-line therapy. Combinations of docetaxel with various novel targeted agents have produced encouraging data in Phase II trials. This review article summarizes recent studies of docetaxel as a single agent and in combination regimens with cytotoxic or targeted therapies in the management of patients with advanced NSCLC. |
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