快速预氧在妇产科门诊手术中的应用

目的 观察术前快速预氧对妇产科门诊手术中因呼吸抑制缺氧患者的预防作用。方法 采用电脑产生随机序列，将拟接受静脉全身麻醉的120例妇产科患者，将病人随机分为快速预氧（试验）组和常规吸氧（对照）组，每组各60例。快速预氧组患者在麻醉前做8次深呼吸，常规吸氧组保持自然呼吸，麻醉方法均为咪唑安定1mg、芬太尼1μg/kg、丙泊酚2mg／kg，术中间断推注丙泊酚。观察麻醉时间、异丙酚总量、术中呼吸抑制和呼吸暂停发生率及呼气末二氧化碳浓度（PetCO2）和SpO2变化情况。结果 两组的一般情况、麻醉时间和丙泊酚用量差异无统计学意义。两组间呼吸抑制和呼吸暂停的发生率差异无统计学意义（P〉0．05）。与快速预氧组相比，常规吸氧组中SpO2值下降更明显，缺氧的发生率更高（P〈0．05）。结论 麻醉前快速预吸氧能增加机体氧储备，提高对缺氧的耐受性，可有效避免门诊手术中呼吸抑制所致的缺氧。

Application of Rapid Preoxygenation Technique in Outpatient Obstetrics-gynecology Operations

Objective To investigate the preventive effect of rapid preoxygenation technique on hypoxia caused by respiratory depression during outpatient obstetrics-gynecology operations. Methods According to a computer-generated random sequence, a total of 120 ASA Ⅰ-Ⅱ patients undergoing outpatient obstetrics-gynecology operations were randomly allocated into the trial group or the control group, 60 in each group. Patients in the control group received preoxygenation with tidal volume breathing. Patients in the trial group received preoxygenation with eight deep breaths （DB） in 1 min before anesthesia. All patients were induced with midazolam 1 mg, fentanyl μg/kg and propofol 2 mg/kg, and were maintained with propofol when needed. The following parameters were observed, including the incidences of respiratory depression and apnea, the onset time of anesthesia, the total doses of propofol as well as the changes in PetCO2 and SpO2. Results No significant differences were observed in demographic characteristics, the onset time of anesthesia, the total doses ofpropofol, and the incidences of respiratory depression and apnea between the two groups （P 〉0.05）. However, the SpO2 in the control group was decreased significantly with a higher incidence of hypoxia （P〈0.05）. Conclusions Rapid preoxygenation technique may increase the oxygen reserves and improve the tolerance to hypoxia. It is effective in avoiding hypoxia caused by respiratory depression and apnea during outpatient obstetrics-gynecology operations.